Thomson A M, Lodge D
Neurosci Lett. 1985 Feb 28;54(1):21-6. doi: 10.1016/s0304-3940(85)80112-9.
In isolated slices of rat cortex, intracellularly recorded responses of pyramidal neurones to N-methylaspartate (NMA) and glutamate and responses to stimulation of the underlying white matter were compared and challenged with the sigma opiate cyclazocine. Cyclazocine blocked responses to iontophoretically applied NMA and one component of the postsynaptic response to stimulation, but left other postsynaptic events and responses to glutamate intact. These results are consistent with the view that sigma opiates act as selective NMA antagonists and block synaptic events mediated by NMA receptors.
在大鼠皮质的离体切片中，比较了细胞内记录的锥体神经元对N-甲基-D-天冬氨酸（NMA）和谷氨酸的反应以及对其下方白质刺激的反应，并使用西格玛阿片类药物环唑辛进行了检验。环唑辛阻断了对离子导入施加的NMA的反应以及对刺激的突触后反应的一个成分，但使其他突触后事件和对谷氨酸的反应保持完整。这些结果与以下观点一致，即西格玛阿片类药物作为选择性NMA拮抗剂，阻断由NMA受体介导的突触事件。
