去甲肾上腺素耗竭对大鼠鞘内注射5-羟色胺诱导的抗伤害感受的阻断作用。
Blockade of intrathecal 5-hydroxytryptamine-induced antinociception in rats by noradrenaline depletion.
作者信息
Minor B G, Post C, Archer T
出版信息
Neurosci Lett. 1985 Feb 28;54(1):39-44. doi: 10.1016/s0304-3940(85)80115-4.
PMID:2983267
Abstract
The analgesic effect of 5-hydroxytryptamine (5-HT, 200 and 250 micrograms/kg) administered into the lumbar intrathecal space of rats was blocked in the tail-flick, hot-plate and shock titration tests of nociception when the animals had previously been treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), which depletes noradrenaline in the spinal cord. These results suggest an important modulatory role of noradrenaline upon spinal 5-HT mechanisms.
摘要
当大鼠预先接受N-2-氯乙基-N-乙基-2-溴苄胺（DSP4）处理（该药物可耗尽脊髓中的去甲肾上腺素）后，在甩尾、热板和伤害性感受的电击滴定试验中，向大鼠腰段鞘内注射5-羟色胺（5-HT，200和250微克/千克）的镇痛作用被阻断。这些结果表明去甲肾上腺素对脊髓5-HT机制具有重要的调节作用。
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