5-甲氧基-N,N-二甲基色胺诱导的镇痛作用在大鼠中被α-肾上腺素能受体拮抗剂阻断。

5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.

作者信息

Archer T, Danysz W, Jonsson G, Minor B G, Post C

出版信息

Br J Pharmacol. 1986 Oct;89(2):293-8. doi: 10.1111/j.1476-5381.1986.tb10259.x.

DOI:10.1111/j.1476-5381.1986.tb10259.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917018/

Abstract

The effects of the alpha-adrenoceptor antagonists prazosin, phentolamine and yohimbine upon 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced analgesia were tested in the hot-plate, tail-flick and shock-titration tests of nociception with rats. Intrathecally injected yohimbine and phentolamine blocked or attenuated the analgesia produced by systemic administration of 5-MeODMT in all three nociceptive tests. Intrathecally administered prazosin attenuated the analgesic effects of 5-MeODMT in the hot-plate and tail-flick tests, but not in the shock titration test. Intrathecal yohimbine showed a dose-related lowering of pain thresholds in saline and 5-MeODMT-treated animals. Phentolamine and prazosin produced normal dose-related curves in the hot-plate test and biphasic effects in the shock titration and tail-flick tests. These results demonstrate a functional interaction between alpha 2-adrenoceptors and 5-HT agonist-induced analgesia at a spinal level in rats.

摘要

在大鼠的热板法、甩尾法和电击滴定法伤害感受试验中，测试了α-肾上腺素能受体拮抗剂哌唑嗪、酚妥拉明和育亨宾对5-甲氧基-N，N-二甲基色胺（5-MeODMT）诱导的镇痛作用。鞘内注射育亨宾和酚妥拉明在所有三种伤害感受试验中均阻断或减弱了全身给予5-MeODMT所产生的镇痛作用。鞘内注射哌唑嗪减弱了5-MeODMT在热板法和甩尾法试验中的镇痛作用，但在电击滴定法试验中未减弱。鞘内注射育亨宾在生理盐水处理和5-MeODMT处理的动物中显示出与剂量相关的痛阈降低。酚妥拉明和哌唑嗪在热板法试验中产生正常的剂量相关曲线，在电击滴定法和甩尾法试验中产生双相效应。这些结果表明，大鼠脊髓水平上α2-肾上腺素能受体与5-羟色胺激动剂诱导的镇痛之间存在功能相互作用。

相似文献

1

5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.5-甲氧基-N,N-二甲基色胺诱导的镇痛作用在大鼠中被α-肾上腺素能受体拮抗剂阻断。

Br J Pharmacol. 1986 Oct;89(2):293-8. doi: 10.1111/j.1476-5381.1986.tb10259.x.

2

Chronic treatment with antidepressant drugs and the analgesia induced by 5-methoxy-N,N-dimethyltryptamine: attenuation by desipramine.抗抑郁药物的长期治疗以及5-甲氧基-N,N-二甲基色胺诱导的镇痛作用：地昔帕明的减弱作用

Acta Pharmacol Toxicol (Copenh). 1986 Aug;59(2):103-12. doi: 10.1111/j.1600-0773.1986.tb00141.x.

3

Intrathecal noradrenaline restores 5-methoxy-N,N-dimethyltryptamine induced antinociception abolished by intrathecal 6-hydroxydopamine.鞘内注射去甲肾上腺素可恢复被鞘内注射6-羟基多巴胺消除的5-甲氧基-N,N-二甲基色胺诱导的抗伤害感受作用。

J Neural Transm. 1988;72(2):107-20. doi: 10.1007/BF01250234.

4

Nociception is enhanced by the intrathecal injection of 5-methoxy-N,N-dimethyltryptamine in the rat.鞘内注射5-甲氧基-N,N-二甲基色胺可增强大鼠的伤害感受。

Neurosci Lett. 1982 Dec 13;33(3):323-8. doi: 10.1016/0304-3940(82)90393-7.

5

Noradrenergic-serotonergic interactions and nociception in the rat.大鼠去甲肾上腺素能与5-羟色胺能的相互作用及痛觉感受

Eur J Pharmacol. 1986 Jan 29;120(3):295-307. doi: 10.1016/0014-2999(86)90470-x.

6

Spinal and locus coeruleus noradrenergic lesions abolish the analgesic effects of 5-methoxy-N,N-dimethyltryptamine.脊髓和蓝斑去甲肾上腺素能损伤消除了5-甲氧基-N,N-二甲基色胺的镇痛作用。

Behav Neural Biol. 1986 Jul;46(1):71-86. doi: 10.1016/s0163-1047(86)90916-7.

7

Analgesia induced by brief footshock: blockade by fenfluramine and 5-methoxy-N,N-dimethyltryptamine and prevention of blockade by 5-HT antagonists.

Brain Res. 1983 Nov 21;279(1-2):105-10. doi: 10.1016/0006-8993(83)90167-1.

8

Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine.鞘内注射哌唑嗪和鞘内注射育亨宾对鞘内应用α肾上腺素能激动剂的抗伤害感受作用的选择性拮抗。

J Pharmacol Exp Ther. 1983 Mar;224(3):552-8.

9

Spinal noradrenergic neurotransmission and the analgesia induced by brief footshock.

Brain Res. 1986 Feb 12;365(1):169-73. doi: 10.1016/0006-8993(86)90735-3.

10

Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine.

Eur J Pharmacol. 1991 Nov 12;204(3):301-9. doi: 10.1016/0014-2999(91)90856-l.

引用本文的文献

1

Intrathecal noradrenaline restores 5-methoxy-N,N-dimethyltryptamine induced antinociception abolished by intrathecal 6-hydroxydopamine.鞘内注射去甲肾上腺素可恢复被鞘内注射6-羟基多巴胺消除的5-甲氧基-N,N-二甲基色胺诱导的抗伤害感受作用。

J Neural Transm. 1988;72(2):107-20. doi: 10.1007/BF01250234.

2

Evidence for crosstolerance to the analgesic effects between morphine and selective alpha 2-adrenoceptor agonists.

J Neural Transm. 1988;72(1):1-9. doi: 10.1007/BF01244627.

3

Evidence that 8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT) is a selective alpha 2-adrenoceptor antagonist on guinea-pig submucous neurones.有证据表明8-羟基-2-（二丙基氨基）四氢萘（8-OH-DPAT）是豚鼠黏膜下神经元上的一种选择性α2-肾上腺素能受体拮抗剂。

Br J Pharmacol. 1987 Oct;92(2):341-7. doi: 10.1111/j.1476-5381.1987.tb11329.x.

本文引用的文献

1

The inhibitory action of noradrenaline and other monoamines on spinal neurones.去甲肾上腺素及其他单胺对脊髓神经元的抑制作用。

J Physiol. 1966 Jul;185(2):298-322. doi: 10.1113/jphysiol.1966.sp007988.

2

Chronic catheterization of the spinal subarachnoid space.脊髓蛛网膜下腔长期置管

Physiol Behav. 1976 Dec;17(6):1031-6. doi: 10.1016/0031-9384(76)90029-9.

3

EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.中枢神经系统中单胺能神经元存在的证据。IV. 中枢神经系统中单胺能神经末梢的分布。

Acta Physiol Scand Suppl. 1965:SUPPL 247:37+.

4

Functional aspects of bulbospinal monoaminergic projections in modulating processing of somatosensory information.延髓脊髓单胺能投射在调节体感信息处理中的功能方面。

Fed Proc. 1981 Nov;40(13):2786-94.

5

Effect of intrathecally administered noradrenergic antagonists on nociception in the rat.

Brain Res. 1984 Sep 24;310(2):295-301. doi: 10.1016/0006-8993(84)90152-5.

6

Nociception is enhanced after low doses and reduced after high doses of the serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine.

Neurosci Lett. 1980 Sep;19(2):219-23. doi: 10.1016/0304-3940(80)90198-6.

7

Spinal noradrenergic terminal system mediates antinociception.脊髓去甲肾上腺素能终末系统介导抗伤害感受。

Brain Res. 1980 May 12;189(2):391-401. doi: 10.1016/0006-8993(80)90099-2.

8

Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor.育亨宾：一种用于研究α2-肾上腺素能受体的药理学探针。

Pharmacol Rev. 1983 Sep;35(3):143-80.

9

Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors.育亨宾和萝芙辛通过阻断5-HT2受体抑制5-羟色胺诱导的小牛大冠状动脉收缩。

Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):149-54. doi: 10.1007/BF00634263.

10

Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration.6-羟基多巴胺（6-OHDA）、5,6-二羟基色胺（5,6-DHT）或重复给予单胺后鞘内注射去甲肾上腺素和5-羟色胺敏感性的变化。

J Pharmacol Exp Ther. 1982 Feb;220(2):311-21.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。