5-甲氧基-N,N-二甲基色胺诱导的镇痛作用在大鼠中被α-肾上腺素能受体拮抗剂阻断。
5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.
作者信息
Archer T, Danysz W, Jonsson G, Minor B G, Post C
出版信息
Br J Pharmacol. 1986 Oct;89(2):293-8. doi: 10.1111/j.1476-5381.1986.tb10259.x.
The effects of the alpha-adrenoceptor antagonists prazosin, phentolamine and yohimbine upon 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced analgesia were tested in the hot-plate, tail-flick and shock-titration tests of nociception with rats. Intrathecally injected yohimbine and phentolamine blocked or attenuated the analgesia produced by systemic administration of 5-MeODMT in all three nociceptive tests. Intrathecally administered prazosin attenuated the analgesic effects of 5-MeODMT in the hot-plate and tail-flick tests, but not in the shock titration test. Intrathecal yohimbine showed a dose-related lowering of pain thresholds in saline and 5-MeODMT-treated animals. Phentolamine and prazosin produced normal dose-related curves in the hot-plate test and biphasic effects in the shock titration and tail-flick tests. These results demonstrate a functional interaction between alpha 2-adrenoceptors and 5-HT agonist-induced analgesia at a spinal level in rats.
在大鼠的热板法、甩尾法和电击滴定法伤害感受试验中，测试了α-肾上腺素能受体拮抗剂哌唑嗪、酚妥拉明和育亨宾对5-甲氧基-N，N-二甲基色胺（5-MeODMT）诱导的镇痛作用。鞘内注射育亨宾和酚妥拉明在所有三种伤害感受试验中均阻断或减弱了全身给予5-MeODMT所产生的镇痛作用。鞘内注射哌唑嗪减弱了5-MeODMT在热板法和甩尾法试验中的镇痛作用，但在电击滴定法试验中未减弱。鞘内注射育亨宾在生理盐水处理和5-MeODMT处理的动物中显示出与剂量相关的痛阈降低。酚妥拉明和哌唑嗪在热板法试验中产生正常的剂量相关曲线，在电击滴定法和甩尾法试验中产生双相效应。这些结果表明，大鼠脊髓水平上α2-肾上腺素能受体与5-羟色胺激动剂诱导的镇痛之间存在功能相互作用。
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