Clavel J P, Emerit J, Thuillier A
Pathol Biol (Paris). 1985 Jan;33(1):61-9.
Membrane phospholipids attack by oxygen free radicals, i.e. lipidoperoxidation, occurs in normal cellular life. This free radicals attack is controlled by a protective system, both enzymatic (superoxide dismutase, catalase, glutahione peroxidase) and non enzymatic (vitamine E). Imbalance between attack and defense can explain many pathological events. In these events, the oxidation products of unsaturated fatty acids are of fundamental importance, in particular those derived from arachidonic acid (prostaglandins, prostacyclins, thromboxanes and leukotrienes).
膜磷脂受氧自由基攻击，即脂质过氧化，发生于正常的细胞生命活动中。这种自由基攻击由一个保护系统控制，该系统包括酶促（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶）和非酶促（维生素E）两部分。攻击与防御之间的失衡可以解释许多病理事件。在这些事件中，不饱和脂肪酸的氧化产物至关重要，尤其是那些源自花生四烯酸的产物（前列腺素、前列环素、血栓素和白三烯）。
