Gutteridge J M, Beard A P, Quinlan G J
Biochem Biophys Res Commun. 1983 Dec 28;117(3):901-7. doi: 10.1016/0006-291x(83)91681-9.
Hydroxyl radicals (OH.) can initiate lipid oxidation by hydrogen abstraction. Transition metals however, particularly iron and copper, stimulate lipid oxidation by reacting with lipid peroxides to form new radical species. The haem-iron protein catalase can react non-specifically with lipid peroxides in this way resulting in loss of their conjugated diene structures. When a superoxide-generating system is used to stimulate lipid autoxidation, catalase can conceivably inhibit the reaction in two ways (A) by decomposing lipid peroxides as they are formed (B) through the removal of hydrogen peroxide preventing OH. radical formation. Results presented here suggest that the latter interpretation, although commonly presented, cannot be automatically assumed.
羟基自由基（OH.）可通过夺取氢引发脂质氧化。然而，过渡金属，尤其是铁和铜，会与脂质过氧化物反应形成新的自由基物种，从而刺激脂质氧化。血红素铁蛋白过氧化氢酶可通过这种方式与脂质过氧化物发生非特异性反应，导致其共轭二烯结构丧失。当使用超氧化物生成系统刺激脂质自氧化时，过氧化氢酶可以通过两种方式抑制该反应：（A）在脂质过氧化物形成时将其分解；（B）通过去除过氧化氢来防止OH.自由基的形成。此处给出的结果表明，后一种解释虽然常见，但不能想当然地认定。
