前列腺素对兔离体输精管神经传递的影响。

The influence of prostaglandins on neurotransmission in the rabbit isolated vas deferens.

作者信息

Trachte G J

出版信息

Prostaglandins. 1985 Jan;29(1):47-59. doi: 10.1016/0090-6980(85)90150-9.

Abstract

Arachidonic acid and PGs of the D, E, F and I series were examined for influences on neurogenic contractions of the rabbit isolated vas deferens. This preparation exhibits two pharmacologically distinct contractions in response to electrical stimulation. All of the PGs tested inhibited the neurogenic contractions but the pattern of inhibition differed. PGE1 and PGI2 inhibited the adrenergic contractile phase more potently than the nonadrenergic, and PGF2 alpha exhibited the opposite selectivity. Arachidonic acid, PGE2 and PGD2 produced equipotent effects on both contractile phases, although PGE2 was the most potent in producing these effects. None of the PGs altered the concentration-response curve to norepinephrine. Contractile responses to ATP, a putative neurotransmitter, were inhibited by PGF2 alpha but not by the other PGs. These results suggest that the PG effects are predominantly prejunctional. The differing potencies of the PGs on the two neural components are consistent with the hypothesis that neurotransmitters in the vas deferens are released by distinct types of nerves.

摘要

研究了花生四烯酸以及D、E、F和I系列前列腺素（PGs）对兔离体输精管神经源性收缩的影响。该制剂对电刺激表现出两种药理学上不同的收缩反应。所有测试的PGs均抑制神经源性收缩，但抑制模式不同。前列腺素E1（PGE1）和前列环素（PGI2）对肾上腺素能收缩相的抑制作用比对非肾上腺素能收缩相更强，而前列腺素F2α（PGF2α）表现出相反的选择性。花生四烯酸、前列腺素E2（PGE2）和前列腺素D2（PGD2）对两个收缩相产生同等效力的作用，尽管PGE2在产生这些作用方面最为有效。没有一种PGs改变去甲肾上腺素的浓度-反应曲线。对假定神经递质三磷酸腺苷（ATP）的收缩反应被PGF2α抑制，但未被其他PGs抑制。这些结果表明PGs的作用主要是在神经节前。PGs对两种神经成分的不同效力与输精管中的神经递质由不同类型的神经释放这一假设一致。