Menna J H, Barnett J B, Soderberg L S
Toxicol Lett. 1985 Jan;24(1):45-52. doi: 10.1016/0378-4274(85)90138-9.
Previous studies carried out by others have shown that in utero exposure of mice to chlordane effects a significant depression of cell-mediated immunity (CMI) at 100 days of life without adversely affecting the humoral immune system. In the studies reported herein we assessed the effect of in utero exposure to various doses of chlordane on the response of 38-day-old mice to influenza type A virus infection in terms of relative levels of mortality, mean day of death, and the levels of antiviral antibody in the primary and secondary immune response to the virus. In utero exposure to chlordane effected enhanced survival to influenza type A virus infection relative to mock-treated animals. No significant differences were noted in the mean day of death of chlordane-treated and mock-treated mice. A significant enhancement in the levels of antiviral antibody was noted in the chlordane-treated female mice but not male mice in both the primary and secondary immune response to the virus.
其他人之前进行的研究表明，子宫内接触氯丹会使小鼠在100日龄时细胞介导免疫（CMI）显著降低，而对体液免疫系统没有不利影响。在本文报道的研究中，我们评估了子宫内接触不同剂量氯丹对38日龄小鼠感染甲型流感病毒的反应的影响，评估指标包括死亡率的相对水平、平均死亡日以及对该病毒的初次和二次免疫反应中抗病毒抗体的水平。与假处理动物相比，子宫内接触氯丹使小鼠对甲型流感病毒感染的存活率提高。氯丹处理组和假处理组小鼠的平均死亡日没有显著差异。在对病毒的初次和二次免疫反应中，氯丹处理的雌性小鼠抗病毒抗体水平显著提高，而雄性小鼠则没有。
