Gabriel L, Escribano L, Perales J, Bellas C, Odriozola J, Navarro J L
Am J Hematol. 1985 Apr;18(4):405-11. doi: 10.1002/ajh.2830180410.
Intracytoplasmic inclusions were observed at light and electron microscopy in the cells of most of the hemopoietic series, including erythroblasts, in a case of multiple myeloma IgG kappa. The inclusions were of crystalline nature, surrounded by smooth membrane. An indirect immunoperoxidase method on thick sections confirmed their immunoglobulin G kappa nature. The fact that crystals were observed in various hemopoietic series suggests that, except for the plasma cells, their presence is more likely due to phagocytosis than to synthesis and, therefore, that they are not a clone marker.
在一例IgG κ型多发性骨髓瘤患者中,通过光镜和电镜观察到大多数造血系列细胞(包括成红细胞)内存在胞浆内包涵体。这些包涵体具有晶体性质,被光滑膜所包围。对厚切片进行的间接免疫过氧化物酶法证实了它们的免疫球蛋白G κ性质。在不同造血系列中均观察到晶体这一事实表明,除浆细胞外,它们的存在更可能是由于吞噬作用而非合成作用,因此它们不是克隆标志物。