Misumi J, Nagano M, Kaisaku J, Hitoshi T
Arch Toxicol. 1985 Jan;56(3):204-6. doi: 10.1007/BF00333428.
The therapeutic effect of Vitamin B12 or Vitamin B6 on 2,5-hexanedione induced-neuropathy in animals was examined by using our electrodiagnostic technique in order to investigate the mechanism of the development of the neuropathy. Pyridoxal phosphate and two forms of Vitamin B12 were administered to rats intoxicated by the neurotoxin for a period of 18 weeks, and the sensory and motor fiber conduction velocity and the motor distal latency of the tail nerve were periodically determined. None of the groups treated with the therapeutic drugs exhibited a definite improvement in the nerve fiber conduction velocity and motor distal latency of the rat tail nerve, as compared with those of the 2,5-hexanedione-treated controls.
为了研究神经病变的发展机制，我们运用电诊断技术检测了维生素B12或维生素B6对动物2,5 -己二酮诱导的神经病变的治疗效果。将磷酸吡哆醛和两种形式的维生素B12给予被神经毒素中毒的大鼠，持续18周，并定期测定尾神经的感觉和运动纤维传导速度以及运动远端潜伏期。与用2,5 -己二酮处理的对照组相比，接受治疗药物治疗的组中，大鼠尾神经的神经纤维传导速度和运动远端潜伏期均未显示出明显改善。
