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1
Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex.N，N'-二环己基碳二亚胺对线粒体细胞色素bc1复合物质子转运影响的热力学和稳态动力学研究
Biochem J. 1985 Jan 15;225(2):407-11. doi: 10.1042/bj2250407.
2
Proton translocation by the mitochondrial cytochrome b-c1 complex is inhibited by NN'-dicyclohexylcarbodi-imide.线粒体细胞色素b-c1复合物的质子转运受到N，N'-二环己基碳二亚胺的抑制。
Biochem J. 1982 Aug 15;206(2):419-21. doi: 10.1042/bj2060419.
3
Chemical modification of the mitochondrial bc1 complex by N,N'-dicyclohexylcarbodiimide inhibits proton translocation.N，N'-二环己基碳二亚胺对线粒体bc1复合物的化学修饰会抑制质子转运。
Eur J Biochem. 1983 May 16;132(3):595-601. doi: 10.1111/j.1432-1033.1983.tb07405.x.
4
The inhibition of proton translocation in the mitochondrial bc1 region by dicyclohexylcarbodiimide.二环己基碳二亚胺对线粒体bc1区域质子转运的抑制作用。
FEBS Lett. 1982 Oct 4;147(1):101-5. doi: 10.1016/0014-5793(82)81020-x.
5
Thermodynamic control of electron flux through mitochondrial cytochrome bc1 complex.通过线粒体细胞色素bc1复合物对电子通量的热力学控制。
Biochem J. 1985 Jan 15;225(2):399-405. doi: 10.1042/bj2250399.
6
Sensitivity to NN'-dicyclohexylcarbodi-imide of proton translocation by mitochondrial NADH:ubiquinone oxidoreductase.线粒体NADH：泛醌氧化还原酶质子转运对N，N'-二环己基碳二亚胺的敏感性
Biochem J. 1986 Aug 1;237(3):927-30. doi: 10.1042/bj2370927.
7
Modification of the catalytic function of the mitochondrial cytochrome b-c1 complex by dicyclohexylcarbodiimide.二环己基碳二亚胺对线粒体细胞色素b-c1复合物催化功能的修饰
Biochim Biophys Acta. 1983 Nov 30;725(2):349-60. doi: 10.1016/0005-2728(83)90209-8.
8
Structural and functional alterations induced in the mitochondrial cytochrome b-c1 complex by N,N'-dicyclohexylcarbodiimide.N，N'-二环己基碳二亚胺诱导线粒体细胞色素b-c1复合物产生的结构和功能改变。
Biochimie. 1983 Aug-Sep;65(8-9):513-8. doi: 10.1016/s0300-9084(83)80133-3.
9
A clarification of the effects of DCCD on the electron transfer and antimycin binding of the mitochondrial bc1 complex.二氯二苯醚对线粒体bc1复合物电子传递和抗霉素结合作用的阐释。
J Bioenerg Biomembr. 1985 Apr;17(2):109-21. doi: 10.1007/BF00744201.
10
DCCD sensitivity of electron and proton transfer by NADH: ubiquinone oxidoreductase in bovine heart submitochondrial particles--a thermodynamic approach.牛心亚线粒体颗粒中NADH：泛醌氧化还原酶介导的电子和质子转移的二环己基碳二亚胺敏感性——一种热力学方法
Biochim Biophys Acta. 1989 May 8;974(2):219-22. doi: 10.1016/s0005-2728(89)80375-5.

引用本文的文献

1
Sensitivity to NN'-dicyclohexylcarbodi-imide of proton translocation by mitochondrial NADH:ubiquinone oxidoreductase.线粒体NADH：泛醌氧化还原酶质子转运对N，N'-二环己基碳二亚胺的敏感性
Biochem J. 1986 Aug 1;237(3):927-30. doi: 10.1042/bj2370927.

本文引用的文献

1
On the location of the H+-extruding steps in site 2 of the mitochondrial electron transport chain.关于线粒体电子传递链位点2中质子外排步骤的位置
J Biol Chem. 1980 Nov 25;255(22):10721-30.
2
N,N'-Dicyclohexylcarbodiimide inhibits monovalent cation influx but not cation/proton exchange in heart mitochondria.N，N'-二环己基碳二亚胺抑制心脏线粒体中的单价阳离子内流，但不抑制阳离子/质子交换。
J Biol Chem. 1980 Jan 25;255(2):408-12.
3
Dicyclohexylcarbodiimide modification of bovine heart mitochondrial transhydrogenase.二环己基碳二亚胺对牛心线粒体转氢酶的修饰作用
J Biol Chem. 1981 Sep 10;256(17):8963-9.
4
Inhibition of electrogenic anion entry into rat liver mitochondria by N,N'-dicyclohexylcarbodiimide.N，N'-二环己基碳二亚胺对大鼠肝线粒体中电生性阴离子进入的抑制作用。
FEBS Lett. 1982 Nov 29;149(2):249-52. doi: 10.1016/0014-5793(82)81110-1.
5
The binding of dicyclohexylcarbodiimide to uncoupling protein in brown adipose tissue mitochondria.二环己基碳二亚胺与棕色脂肪组织线粒体中解偶联蛋白的结合。
FEBS Lett. 1982 Jul 19;144(1):6-10. doi: 10.1016/0014-5793(82)80557-7.
6
Identification of an 82,000-dalton protein responsible for K+/H+ antiport in rat liver mitochondria.鉴定一种负责大鼠肝线粒体中钾离子/氢离子反向转运的82,000道尔顿蛋白质。
J Biol Chem. 1984 Feb 25;259(4):2062-5.
7
Electron and proton transfers through quinones and cytochrome bc complexes.电子和质子通过醌类和细胞色素bc复合物的转移。
Biochim Biophys Acta. 1984 Apr 9;768(1):53-79. doi: 10.1016/0304-4173(84)90007-7.
8
Redox-linked proton translocation in the b-c1 complex from beef-heart mitochondria reconstituted into phospholipid vesicles. Studies with chemical modifiers of amino acid residues.重新构建到磷脂囊泡中的牛心线粒体b-c1复合物中与氧化还原相关的质子转运。氨基酸残基化学修饰剂的研究。
Eur J Biochem. 1983 Dec 15;137(3):413-20. doi: 10.1111/j.1432-1033.1983.tb07844.x.
9
Dicyclohexylcarbodiimide blocks proton ejection and affects antimycin binding but not electron transport in complex III from yeast mitochondria.二环己基碳二亚胺可阻止质子排出并影响抗霉素的结合，但不影响酵母线粒体复合体III中的电子传递。
J Biol Chem. 1983 Dec 10;258(23):14271-5.
10
Structural and functional alterations induced in the mitochondrial cytochrome b-c1 complex by N,N'-dicyclohexylcarbodiimide.N，N'-二环己基碳二亚胺诱导线粒体细胞色素b-c1复合物产生的结构和功能改变。
Biochimie. 1983 Aug-Sep;65(8-9):513-8. doi: 10.1016/s0300-9084(83)80133-3.

N，N'-二环己基碳二亚胺对线粒体细胞色素bc1复合物质子转运影响的热力学和稳态动力学研究

Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex.

作者信息

Brand M D, Al-Shawi M K, Brown G C, Price B D

出版信息

Biochem J. 1985 Jan 15;225(2):407-11. doi: 10.1042/bj2250407.

DOI:10.1042/bj2250407
PMID:2983671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144604/
Abstract

Steady-state kinetic measurements showed that NN'-dicyclohexylcarbodi-imide decreased the observed H+/2e ratio of H+ transport by mitochondria respiring on succinate, acting mainly at the cytochrome bc1 complex. Thermodynamic assessment of the H+/2e ratio by measuring the force ratio across the bc1 complex showed that the inhibitor did not affect H+ translocation. Possible explanations of this disagreement between methods are examined; we conclude that the inhibitor does not alter the mechanistic stoichiometry of H+ pumping by the bc1 complex.

摘要

稳态动力学测量表明，N，N'-二环己基碳二亚胺降低了琥珀酸呼吸的线粒体中观察到的H⁺/2e⁺的H⁺转运比率，主要作用于细胞色素bc1复合体。通过测量bc1复合体两侧的力比来对H⁺/2e⁺比率进行热力学评估，结果表明该抑制剂不影响H⁺的转运。本文研究了两种方法之间这种差异的可能解释；我们得出结论，该抑制剂不会改变bc1复合体泵送H⁺的机制化学计量。