Sullivan J L, Wallen W C, Johnson F L
Int J Cancer. 1978 Aug 15;22(2):132-5. doi: 10.1002/ijc.2910220205.
A 12-year-old patient with acute lymphoblastic leukemia received a bone-marrow transplant (BMT) from a matched sibling donor. Nine weeks prior to transplant the donor experienced Epstein-Barr virus (EBV)-induced infectious mononucleosis. The bone-marrow recipient was EBV-negative at the time of transplant; however, 4 weeks post transplant the recipient developed clinical symptoms of graft-verus-host disease (GVHD) coincident with serological evidence of acute EBV infection. In addition, a lymphoblastoid cell line positive for Epstein-Barr nuclear antigen was established from a bone-marrow sample obtained at the onset of symptoms compatible with GVHD. Sera obtained from the recipient over the ensuing 2 months showed the appearance of antibodies to specific EBV antigens consistent with a primary immune response to EBV infection. This association of acute EBV infection with symptoms of GVHD in a BMT recipient suggests a need for further investigation of the epidemiology of EBV infections in human bone-marrow transplantation and the relationship between EBV infection and GVHD.
一名12岁的急性淋巴细胞白血病患者接受了来自匹配同胞供体的骨髓移植（BMT）。移植前9周， donor出现了由爱泼斯坦-巴尔病毒（EBV）引起的传染性单核细胞增多症。骨髓受体在移植时EBV呈阴性；然而，移植后4周，受体出现了移植物抗宿主病（GVHD）的临床症状，同时伴有急性EBV感染的血清学证据。此外，从出现与GVHD相符症状时获取的骨髓样本中建立了一种对爱泼斯坦-巴尔核抗原呈阳性的淋巴母细胞系。在随后的2个月里从受体获取的血清显示出现了针对特定EBV抗原的抗体，这与对EBV感染的原发性免疫反应一致。这种急性EBV感染与BMT受体中GVHD症状的关联表明需要进一步研究人类骨髓移植中EBV感染的流行病学以及EBV感染与GVHD之间的关系。
