Dashwood M R, Debnam E S, Bagnall J, Thompson C S
Eur J Pharmacol. 1985 Jan 2;107(2):267-9. doi: 10.1016/0014-2999(85)90068-8.
[3H]Naloxone and [3H]dihydromorphine are selective ligands for opiate receptors. Using an in vitro autoradiographic technique, binding of these ligands has been demonstrated to the villi and crypts in rat small intestine. These results indicate the presence of opiate receptor sites in the small intestine which suggests further a role for endogenous opiates in the transport functions of intestinal mucosa.
[3H]纳洛酮和[3H]二氢吗啡是阿片受体的选择性配体。利用体外放射自显影技术，已证实在大鼠小肠的绒毛和隐窝中有这些配体的结合。这些结果表明小肠中存在阿片受体位点，这进一步提示内源性阿片在肠黏膜转运功能中发挥作用。
