Kameyama T, Nabeshima T, Matsuno K, Suzuki M
Neurosci Lett. 1984 Aug 31;49(3):307-12. doi: 10.1016/0304-3940(84)90307-0.
Electric shock (ES) produces an opiate-like analgesia and catalepsy in rats, which may be mediated by endogenous opioid systems. The present study was designed to investigate the alterations of endogenous opioid receptors by an intermittent ES application. In a case of opiate agonists, [3H]dihydromorphine and [3H]D-Ala-Met-enkephalinamide, the application of ES produced a decrease of [3H]ligands' binding capacity. On the contrary, the binding capacity of the opiate antagonist [3H]naloxone was increased by the ES application. These results suggest that endogenous putative opioid agonist- and antagonist-type receptors are differently regulated in vivo.
电击（ES）可在大鼠中产生类阿片样镇痛和僵住症，这可能由内源性阿片系统介导。本研究旨在通过间歇性施加ES来研究内源性阿片受体的变化。对于阿片激动剂[3H]二氢吗啡和[3H]D-丙氨酸-甲硫氨酸-脑啡肽酰胺，施加ES会导致[3H]配体结合能力下降。相反，施加ES会增加阿片拮抗剂[3H]纳洛酮的结合能力。这些结果表明，内源性假定的阿片激动剂型和拮抗剂型受体在体内受到不同的调节。
