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点燃诱导的癫痫发作后齿状回抑制性过程的改变。

Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy.

作者信息

Oliver M W, Miller J J

出版信息

Exp Brain Res. 1985;57(3):443-7. doi: 10.1007/BF00237830.

DOI:10.1007/BF00237830
PMID:2984035
Abstract

In vitro hippocampal slices were prepared from control and commissural-kindled rats and the inhibitory processes of the dentate granule cells were assessed using paired perforant path stimulation. An early (20 ms) Cl(-)-dependent and a late (200 ms-8 s) Cl(-)-independent inhibition were shown to be present in the dentate. Enhancement of the late Cl(-)-insensitive inhibition was observed following the establishment of commissural kindling and persisted for periods of up to eight weeks following the last seizure.

摘要

从对照大鼠和连合点燃大鼠制备体外海马切片,并使用成对的穿通通路刺激评估齿状颗粒细胞的抑制过程。结果显示,齿状回中存在早期(20毫秒)氯离子依赖性抑制和晚期(200毫秒至8秒)氯离子非依赖性抑制。在连合点燃建立后观察到晚期氯离子不敏感抑制增强,并且在最后一次癫痫发作后持续长达八周。

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1
Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy.点燃诱导的癫痫发作后齿状回抑制性过程的改变。
Exp Brain Res. 1985;57(3):443-7. doi: 10.1007/BF00237830.
2
Abnormal neuronal excitability in hippocampal slices from kindled rats.点燃大鼠海马切片中神经元兴奋性异常。
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Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling.未成熟海马体对癫痫持续状态或点燃后形态学和生理学改变的抵抗性。
Hippocampus. 2001;11(6):615-25. doi: 10.1002/hipo.1076.
4
Alteration in dentate neuronal activities associated with perforant path kindling. III. Enhancement of synaptic inhibition.
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The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression.点燃对大鼠齿状回中γ-氨基丁酸介导的抑制作用的影响。I. 双脉冲抑制
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Development of changes in endogenous GABA release during kindling epileptogenesis in rat hippocampus.大鼠海马点燃癫痫发生过程中内源性γ-氨基丁酸释放变化的发展
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Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats.点燃及 kainic 酸处理大鼠齿状回中的反复兴奋性连接
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NMDA-dependent currents in granule cells of the dentate gyrus contribute to induction but not permanence of kindling.齿状回颗粒细胞中依赖N-甲基-D-天冬氨酸(NMDA)的电流有助于点燃的诱导,但对其持续性没有影响。
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Kindling induces transient NMDA receptor-mediated facilitation of high-frequency input in the rat dentate gyrus.点燃效应诱导大鼠齿状回中由N-甲基-D-天冬氨酸受体介导的高频输入的短暂易化。
J Neurophysiol. 2001 May;85(5):2195-202. doi: 10.1152/jn.2001.85.5.2195.

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本文引用的文献

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Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.脑源性神经营养因子转基因小鼠表现出被动回避缺陷、癫痫发作严重程度增加以及海马体和内嗅皮质的体外兴奋性过高。
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