Miller D L, Rayner A A, Girton M, Doppman J L
Invest Radiol. 1985 Jan-Feb;20(1):68-72. doi: 10.1097/00004424-198501000-00018.
EOE-13 is a liver-spleen specific CT contrast agent currently undergoing clinical trials. It is an aqueous emulsion of iodinated fatty acids. We studied eight rhesus monkeys with surgically created blunt trauma to the liver and spleen. The animals were examined using CT scans without contrast material and CT scans with EOE-13. Scans were performed at times between 3 hours and 24 hours after trauma. The presence of parenchymal injury was shown better EOE-13 (P less than 0.01). The use of EOE-13 permitted earlier diagnosis in both the liver and spleen. This contrast agent has potential for the evaluation of trauma in clinical practice, and may be particularly useful in children.
EOE - 13是一种目前正在进行临床试验的肝脾特异性CT造影剂。它是碘化脂肪酸的水包油乳剂。我们研究了八只经手术造成肝脾钝性创伤的恒河猴。这些动物在未使用造影剂的情况下接受CT扫描，并在使用EOE - 13后接受CT扫描。扫描在创伤后3小时至24小时之间进行。EOE - 13能更好地显示实质损伤（P小于0.01）。使用EOE - 13可对肝脏和脾脏进行更早的诊断。这种造影剂在临床实践中具有评估创伤的潜力，对儿童可能特别有用。
