Hoskins S G, Grobstein P
J Neurosci. 1985 Apr;5(4):911-9. doi: 10.1523/JNEUROSCI.05-04-00911.1985.
The distribution of ipsilaterally and contralaterally projecting cells within the retina in Xenopus laevis was studied by injection of horseradish peroxidase into the thalamus on one side of the brain and subsequent determination of the locations of retrogradely labeled cells in both retinas. In normal animals, contralaterally projecting cells were found throughout the retina. Ipsilaterally projecting cells, in contrast, were most frequent in temporoventral retina and largely absent from dorsonasal retina as well as from a region surrounding the nerve head. A similarly restricted distribution of ipsilaterally projecting cells was observed in retinas of animals after regeneration of one optic nerve as well as in animals from which one eye was removed prior to the time when the ipsilateral projection first develops. The restricted distribution of ipsilaterally projecting cells in normal animals raises the possibility that these cells may be produced relatively late in development. This hypothesis is explored in the following paper (Hoskins, S.G., and P. Grobstein (1985) J. Neurosci. 5: 920-929). The fact that similar distributions were seen in normal and experimental animals implies that organization of the ipsilateral retinothalamic projection in X. laevis is not critically dependent either on particular patterns of axonal organization which may be present during normal development or on interactions among fibers from the two eyes.
通过向非洲爪蟾一侧大脑的丘脑注射辣根过氧化物酶，并随后确定两侧视网膜中逆行标记细胞的位置，研究了非洲爪蟾视网膜内同侧和对侧投射细胞的分布。在正常动物中，对侧投射细胞遍布整个视网膜。相比之下，同侧投射细胞在颞腹侧视网膜中最为常见，在背鼻侧视网膜以及视乳头周围区域基本不存在。在一侧视神经再生后的动物视网膜中，以及在同侧投射首次发育之前摘除一只眼睛的动物视网膜中，也观察到了同侧投射细胞类似的局限分布。正常动物中同侧投射细胞的这种局限分布增加了一种可能性，即这些细胞可能在发育后期相对较晚产生。该假说将在后续论文中进行探讨（霍斯金斯，S.G.，和P.格罗布斯坦（1985年）《神经科学杂志》5: 920 - 929）。在正常动物和实验动物中观察到相似分布这一事实意味着，非洲爪蟾同侧视网膜丘脑投射的组织，既不关键依赖于正常发育过程中可能存在的特定轴突组织模式，也不依赖于来自双眼的纤维之间的相互作用。
