Ismail Siti-Aishah, Mutalib Haliza Abdul, Ngah Nor Fariza
Optometry & Vision Science Program, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Optometry & Vision Science Program, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
J Optom. 2019 Jul-Sep;12(3):174-179. doi: 10.1016/j.optom.2018.03.007. Epub 2018 May 26.
The purpose of this study was to determine the relationship between HbA1c values and retinal sensitivity at central 10° using the MP-1 microperimeter.
A prospective study was carried out on 32 healthy subjects (control group) and 60 diabetic patients. The diabetic patients were divided into 2 groups. Group 1 comprised of 30 patients without diabetic retinopathy (DR) and group 2 had 30 patients with mild non-proliferative DR. A full-threshold microperimetry of the central 10° of retina (the macula) was performed on all subjects, utilizing 32 points with the MP-1. The relationship between light sensitivity and HbA1c value was calculated using linear regression analysis.
Total mean sensitivity at 10° for group 1 without DR, group 2 with mild NPDR and control group were 18.67±0.83, 17.98±1.42 and 19.45±0.34 (dB), respectively. There was a significant difference in total mean retinal sensitivity at 10° between the 3 groups (F(2,89)=18.14, p=0.001). A simple linear regression was calculated to predict HbA1c based on retinal sensitivity. A significant regression equation was found (F(1,90)=107.61, p=0.0001, with an R of 0.545). The linear regression analysis revealed that there was a 0.64dB decline in mean retinal sensitivity within the central 10° diameter with an increase of 1mmHg of HbA1c.
Retinal sensitivity at the central 10° of the macula is affected by changes in HbA1c values.
本研究旨在使用MP-1微视野计确定糖化血红蛋白（HbA1c）值与中心10°视网膜敏感度之间的关系。
对32名健康受试者（对照组）和60名糖尿病患者进行了一项前瞻性研究。糖尿病患者被分为两组。第1组由30名无糖尿病视网膜病变（DR）的患者组成，第2组有30名轻度非增殖性DR患者。使用MP-1对所有受试者的视网膜中心10°（黄斑）进行全阈值微视野检查，共32个点。使用线性回归分析计算光敏感度与HbA1c值之间的关系。
第1组无DR、第2组轻度NPDR和对照组在10°的总平均敏感度分别为18.67±0.83、17.98±1.42和19.45±0.34（dB）。三组之间在10°的总平均视网膜敏感度上存在显著差异（F(2,89)=18.14，p=0.001）。计算了一个基于视网膜敏感度预测HbA1c的简单线性回归。发现了一个显著的回归方程（F(1,90)=107.61，p=0.0001，R为0.545）。线性回归分析显示，随着HbA1c每增加1mmHg，中心10°直径内的平均视网膜敏感度下降0.64dB。
黄斑中心10°的视网膜敏感度受HbA1c值变化的影响。
