Brewington Beatrice Y, Shao Yusra F, Davidorf Fredrick H, Cebulla Colleen M
Havener Eye Institute, Department of Ophthalmology and Visual Science, Ohio State University.
Medical Student Research Program, The Ohio State University College of Medicine, Columbus, OH, USA.
Clin Ophthalmol. 2018 May 17;12:925-934. doi: 10.2147/OPTH.S129645. eCollection 2018.
Surgical management with enucleation was the primary treatment for uveal melanoma (UM) for over 100 years. The Collaborative Ocular Melanoma Study confirmed in 2001 that globe-preserving episcleral brachytherapy for UM was safe and effective, demonstrating no survival difference with enucleation. Today, brachytherapy is the most common form of radiotherapy for UM. We review the history of brachytherapy in the treatment of UM and the evolution of the procedure to incorporate fine-needle-aspiration biopsy techniques with DNA-and RNA-based genetic prognostic testing.
眼球摘除术的手术治疗是100多年来葡萄膜黑色素瘤(UM)的主要治疗方法。2001年,眼部黑色素瘤协作研究证实,对于UM,保留眼球的巩膜近距离放射治疗是安全有效的,与眼球摘除术相比,生存率无差异。如今,近距离放射治疗是UM最常见的放射治疗形式。我们回顾了近距离放射治疗在UM治疗中的历史,以及该手术的演变,以纳入基于DNA和RNA的基因预后检测的细针穿刺活检技术。