Kania Aleksander, Krenke Rafał, Kuziemski Krzysztof, Czajkowska-Malinowska Małgorzata, Celejewska-Wójcik Natalia, Kuźnar-Kamińska Barbara, Farnik Małgorzata, Bokiej Juliusz, Miszczuk Marta, Damps-Konstańska Iwona, Grabicki Marcin, Trzaska-Sobczak Marzena, Sładek Krzysztof, Batura-Gabryel Halina, Barczyk Adam
Department of Pulmonology, II Chair of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.
Int J Chron Obstruct Pulmon Dis. 2018 May 17;13:1613-1621. doi: 10.2147/COPD.S154716. eCollection 2018.
This study aimed to examine the distribution of predefined phenotypes, demographic data, clinical outcomes, and treatment of patients who were included in the Polish cohort of the Phenotypes of COPD in Central and Eastern Europe (POPE) study.
This was a sub-analysis of the data from the Polish cohort of the POPE study, an international, multicenter, observational cross-sectional survey of COPD patients in Central and Eastern European countries. The study included patients aged >40 years, with a confirmed diagnosis of COPD, and absence of exacerbation for at least 4 weeks before study inclusion. A total of seven Polish centers participated in the study.
Among the 430 Polish COPD patients enrolled in the study, 61.6% were non-exacerbators (NON-AE), 25.3% were frequent exacerbators with chronic bronchitis (AE CB), 7.9% were frequent exacerbators without chronic bronchitis (AE NON-CB), and 5.1% met the definition of asthma-COPD overlap syndrome (ACOS). There were statistically significant differences among these phenotypes in terms of symptom load, lung function, comorbidities, and treatment. Patients with the AE CB phenotype were most symptomatic with worse lung function, and more frequently reported anxiety and depression. Patients with the ACOS phenotype were significantly younger and were diagnosed with COPD earlier than those with other COPD phenotypes; those with the ACOS phenotype were also more often atopic and obese.
There is significant heterogeneity among COPD patients in the Polish population in terms of phenotype and clinical outcome. The non-exacerbator phenotype is observed most frequently in Poland, while the frequent exacerbator with chronic bronchitis phenotype is the most symptomatic.
本研究旨在调查纳入中东欧慢性阻塞性肺疾病（COPD）表型研究（POPE）波兰队列的患者中预先定义的表型分布、人口统计学数据、临床结局及治疗情况。
这是对POPE研究波兰队列数据的一项亚分析，该研究是一项针对中东欧国家COPD患者的国际多中心观察性横断面调查。研究纳入年龄大于40岁、确诊为COPD且在纳入研究前至少4周无病情加重的患者。共有7个波兰中心参与了该研究。
在纳入研究的430例波兰COPD患者中，61.6%为非加重型（NON - AE），25.3%为慢性支气管炎频繁加重型（AE CB），7.9%为无慢性支气管炎频繁加重型（AE NON - CB），5.1%符合哮喘 - COPD重叠综合征（ACOS）的定义。这些表型在症状负荷、肺功能、合并症及治疗方面存在统计学显著差异。AE CB表型的患者症状最明显，肺功能最差，且更频繁地报告焦虑和抑郁。ACOS表型的患者明显更年轻，被诊断为COPD的时间早于其他COPD表型患者；ACOS表型的患者也更常为特应性体质且肥胖。
波兰人群中COPD患者在表型和临床结局方面存在显著异质性。在波兰，非加重型表型最为常见，而慢性支气管炎频繁加重型表型症状最明显。
