Lee Inhwan, Cho Jinkyung, Hong Haeryun, Jin Youngyun, Kim Donghyun, Kang Hyunsik
College of Sport Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
Iran J Public Health. 2018 Mar;47(3):327-334.
Sarcopenia has been implicated in the increased risk for cognitive impairment and depression associated with aging. In this cross-sectional study, we investigated the relationship of sarcopenia with cognitive impairment (MCI) and depression in a sample of 201 community-dwelling Korean women (mean age of 74.0±6.8 yr) between 2014 and 2015.
The Korean version of mini-mental state examination and the center for epidemiologic studies depression scale was used to assess cognitive performance and depression, respectively. Grp strength was measured with a dynamometer. Demographics, body composition, education, alcohol consumption, and history of cardiovascular diseases were assessed as covariates.
Odds ratio (OR) and 95% confidence interval (95% CI) of MCI and depression were calculated according to sarcopenia status. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 2.160 (95% CI of 0.840 - 5.554, =0.030) and of 5.493 (95% CI of 1.854 - 16.270, =0.002) for MCI. The OR of pre-sarcopenia for MCI remained significant (=0.030) even after adjustments for age, body mass index (BMI), lean body mass, and education, while the OR of sarcopenia for MCI was no longer significant (=0.084) when adjusted for the covariates. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 3.750 (95% CI of 1.137 - 12.370, =0.030) and of 4.687 (95% CI of 1.127-19.505, =0.034) for depression. The ORs of pre-sarcopenia and sarcopenia for depression remained statistically significant (=0.020 and =0.042, respectively) even after adjusted for the covariates.
Sarcopenia was significantly associated with MCI and depression in otherwise healthy community dwelling elderly Korean women.
肌肉减少症与衰老相关的认知障碍和抑郁症风险增加有关。在这项横断面研究中，我们于2014年至2015年期间，在201名居住在社区的韩国女性样本（平均年龄74.0±6.8岁）中，调查了肌肉减少症与认知障碍（轻度认知障碍）和抑郁症之间的关系。
分别使用韩国版简易精神状态检查表和流行病学研究中心抑郁量表来评估认知表现和抑郁情况。用测力计测量握力。将人口统计学、身体成分、教育程度、饮酒情况和心血管疾病史作为协变量进行评估。
根据肌肉减少症状态计算轻度认知障碍和抑郁症的比值比（OR）及95%置信区间（95%CI）。与非肌肉减少症女性相比，肌肉减少症前期和肌肉减少症女性患轻度认知障碍的OR分别为2.160（9%CI为0.8-5.554，P=0.030）和5.493（95%CI为1.854-16.270，P=0.002）。即使在对年龄、体重指数（BMI）、去脂体重和教育程度进行调整后，肌肉减少症前期患轻度认知障碍的OR仍具有统计学意义（P=0.030），而在对协变量进行调整后，肌肉减少症患轻度认知障碍的OR不再具有统计学意义（P=0.084））。与非肌肉减少症女性相比，肌肉减少症前期和肌肉减少症女性患抑郁症的OR分别为3.750（95%CI为1.137-12.370，P=0.030）和4.687（95%CI为1.127-19.505，P=0.034）。即使在对协变量进行调整后，肌肉减少症前期和肌肉减少症患抑郁症的OR仍具有统计学意义（分别为P=0.020和P=0.042）。
在其他方面健康的居住在社区的老年韩国女性中，肌肉减少症与轻度认知障碍和抑郁症显著相关。
