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miR-637 的下调通过靶向瘢痕疙瘩中的 Smad3 促进增殖和转移。

Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids.

机构信息

Department of Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, P.R. China.

出版信息

Mol Med Rep. 2018 Aug;18(2):1628-1636. doi: 10.3892/mmr.2018.9099. Epub 2018 May 29.

DOI:10.3892/mmr.2018.9099
PMID:29845237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6072149/
Abstract

Keloids are a type of abnormal scar tissue. MicroRNAs (miRNAs) exhibit a pivotal role in the regulation of cell proliferation and metastasis of keloids. miRNA microarray revealed that miR‑637 was one of the most frequently altered miRNAs in keloids. Furthermore, up-regulation of miR‑637 inhibited cell proliferation and metastasis by targeting mothers against decapentaplegic homolog (Smad)3, one of the important proteins that affects the formation of keloids. Further studies demonstrated that miR‑637 regulated the proliferation and metastasis of human keloid fibroblast (HKF) cells by mediating the Smad3 signaling pathway. Overall, the present findings suggest that miR‑637 may be a promising therapeutic target in keloids.

摘要

瘢痕疙瘩是一种异常的疤痕组织。微小 RNA（miRNA）在瘢痕疙瘩细胞增殖和转移的调控中发挥着关键作用。miRNA 芯片显示 miR-637 是瘢痕疙瘩中最常改变的 miRNA 之一。此外，上调 miR-637 通过靶向影响瘢痕疙瘩形成的重要蛋白之一母系抗 decapentaplegic 同源物（Smad）3，抑制细胞增殖和转移。进一步的研究表明，miR-637 通过调节 Smad3 信号通路来调节人瘢痕疙瘩成纤维细胞（HKF）细胞的增殖和转移。总的来说，这些发现表明 miR-637 可能是瘢痕疙瘩有前途的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/a343b67e4664/MMR-18-02-1628-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/cf00f805b5e6/MMR-18-02-1628-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/ebbe4f56a369/MMR-18-02-1628-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/ada008325e90/MMR-18-02-1628-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/6e3ae47d29ca/MMR-18-02-1628-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/a343b67e4664/MMR-18-02-1628-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/cf00f805b5e6/MMR-18-02-1628-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/ebbe4f56a369/MMR-18-02-1628-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/ada008325e90/MMR-18-02-1628-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/6e3ae47d29ca/MMR-18-02-1628-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e2/6072149/a343b67e4664/MMR-18-02-1628-g04.jpg

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2
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Biochem Biophys Res Commun. 2018 Jan 1;495(1):713-720. doi: 10.1016/j.bbrc.2017.10.070. Epub 2017 Oct 16.
3
Selenium modulates MMP2 expression through the TGFβ1/Smad signalling pathway in human umbilical vein endothelial cells and rabbits following lipid disturbance.
Int Wound J. 2023 Aug;20(6):2190-2206. doi: 10.1111/iwj.14097. Epub 2023 Feb 1.
4
Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1.环状 RNA 0057452 通过海绵吸附 miR-7-5p 促进瘢痕疙瘩进展，通过上调 GAB1 实现。
Cell Cycle. 2022 Dec;21(23):2471-2483. doi: 10.1080/15384101.2022.2102796. Epub 2022 Jul 25.
5
Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid.瘢痕疙瘩中肿瘤生物分子的发病机制及临床应用前景研究进展
Burns Trauma. 2022 Jun 25;10:tkac025. doi: 10.1093/burnst/tkac025. eCollection 2022.
6
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7
MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression.微小RNA-4328通过靶向BCL2表达抑制瘢痕疙瘩成纤维细胞的增殖、转移并诱导其凋亡。
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8
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9
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10
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Elife. 2020 Nov 10;9:e58178. doi: 10.7554/eLife.58178.
在脂质紊乱后的人脐静脉内皮细胞和兔子中，硒通过TGFβ1/Smad信号通路调节MMP2表达。
J Trace Elem Med Biol. 2017 Jul;42:59-67. doi: 10.1016/j.jtemb.2017.04.006. Epub 2017 Apr 23.
4
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5
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6
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Sci Rep. 2016 Nov 29;6:38033. doi: 10.1038/srep38033.
7
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Int J Mol Med. 2016 Dec;38(6):1857-1863. doi: 10.3892/ijmm.2016.2797. Epub 2016 Nov 8.
8
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9
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