近期提高硼二吡咯亚甲基（BODIPY）用于光动力癌症治疗的策略：最新综述。
Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review.
机构信息
Department of Diagnostic and Allied Health Sciences, Faculty of Health and Life Sciences, Management & Science University, 40100 Shah Alam, Selangor, Malaysia.
Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
出版信息
Photochem Photobiol Sci. 2018 Nov 1;17(11):1691-1708. doi: 10.1039/c8pp00113h. Epub 2018 May 30.
BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (O) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.
BODIPYs 是一种可通过光照激活的光敏剂，可将分子氧转化为具有高反应活性的单线态氧（O），从而导致光照射区域的组织损伤。尽管它们具有非凡的光物理特性，但它们并未在临床光动力疗法中得到应用。本文综述了 2013 年以来 BODIPYs 的设计和/或修饰方面的最新进展，以提高其在光动力癌症治疗及相关领域的应用潜力。
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