噻吩并吡咯扩展的 BODIPY 作为一种潜在的近红外光敏剂用于光动力疗法。
Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy.
机构信息
State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing 210093, PR China.
出版信息
Chem Commun (Camb). 2013 May 11;49(38):3940-2. doi: 10.1039/c3cc40746b. Epub 2013 Mar 27.
The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.
报告了一种高度光稳定的溴取代 BODIPY 染料（I）的合成和表征，该染料通过噻吩并吡咯部分融合环扩展。在活 HeLa 细胞中的 MTT 测定和流式细胞分析结果表明，I 具有高单线态氧量子产率（ΦΔ = 0.63），并且在 NIR 区域照射下表现出光细胞毒性，使其在 PDT 中具有潜在的应用价值。
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