一种实用且选择性化学计量的氨游离伯奇还原反应。
A Practical and Chemoselective Ammonia-Free Birch Reduction.
机构信息
College of Science , China Agricultural University , No. 2 Yuanmingyuan West Road , Beijing 100193 , China.
出版信息
Org Lett. 2018 Jun 15;20(12):3439-3442. doi: 10.1021/acs.orglett.8b00891. Epub 2018 May 30.
PMID:29846078
Abstract
A novel protocol for a significantly improved, practical, and chemoselective ammonia-free Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 ether is reported. A broad range of aromatic and heteroaromatic compounds is reduced with excellent yields.
摘要
报告了一种新型的改进的、实用的和选择性的氨自由 Birch 还原方法，该方法由稳定的钠分散体和可回收的 15-冠-5 醚介导。该方法可用于还原广泛的芳香族和杂环族化合物，产率优异。
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