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[移行和回旋障碍]

[Disorders of migration and gyration].

作者信息

Pogledic I

机构信息

Universitätsklinik für Radiologie und Nuklearmedizin, Klinische Abteilung für Neuroradiologie und Muskuloskeletale Radiologie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

出版信息

Radiologe. 2018 Jul;58(7):653-658. doi: 10.1007/s00117-018-0400-x.

Abstract

Disorders of migration and gyration are a versatile group of pathologies that may cause epilepsy and/or neurodevelopmental delay. With the recent improvement of imaging methods, it is possible to detect these pathologies, not only on postnatal MRI but also in utero using fetal MRI. The use of MRI together with genetic tests and knowledge of the classification of these malformations makes early diagnosis possible. Furthermore, the exact diagnosis of disorders of gyration and migration will help ensure better treatment of symptomatic epilepsies as well as be of great help in counselling the parents if detected in utero. Ultimately, it may enable the development of new treatment strategies. Therefore, in this review the fetal neuroanatomy and pathologies due to migration and abnormal postmigratory processes together with the recent classification of these malformations are elucidated, which will ensure early diagnosis of these types of developmental disorders.

摘要

神经元移行和回旋异常是一组多样的病理情况,可导致癫痫和/或神经发育迟缓。随着近年来成像方法的改进,不仅可以在出生后的磁共振成像(MRI)上检测到这些病变,还可以在子宫内使用胎儿MRI检测到。将MRI与基因检测以及这些畸形的分类知识相结合,使得早期诊断成为可能。此外,准确诊断神经元回旋和移行异常将有助于更好地治疗症状性癫痫,并且如果在子宫内检测到,对为父母提供咨询也有很大帮助。最终,这可能会促成新治疗策略的发展。因此,在本综述中,阐述了胎儿神经解剖结构以及由于神经元移行和迁移后异常过程导致的病变,以及这些畸形的最新分类,这将确保对这类发育障碍进行早期诊断。

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