环磷酸腺苷（cAMP）与其他辐射防护剂对大鼠腮腺慢性损伤的比较。

Comparison of cAMP with other radioprotectors against chronic damage to the rat parotid gland.

作者信息

Conger A D, Sodicoff M, Samel A

出版信息

Radiat Res. 1985 Apr;102(1):99-105.

Abstract

Radiation damage to the parotid gland is protectable by cAMP during the first week after irradiation (acute phase), though appreciable recovery occurred later with or without such protection. Further damage developed later (chronic phase, 60-90 days), and cAMP was still protective against this damage with a dose modification factor of 1.86 for gland weight. A summary of the protective factors, acute and chronic, for WR-2721, isoproterenol, and cAMP is included. Chronic damage is about 1.5 times as great as acute, and protection against acute and chronic damage is about equal for all three compounds.

摘要

腮腺的辐射损伤在照射后的第一周（急性期）可通过环磷酸腺苷（cAMP）得到保护，不过无论有无这种保护，后期都会有明显的恢复。后期（慢性期，60 - 90天）会出现进一步损伤，而cAMP对这种损伤仍有保护作用，对腺体重量而言剂量修正因子为1.86。文中包含了WR - 2721、异丙肾上腺素和cAMP的急性和慢性保护因子总结。慢性损伤约为急性损伤的1.5倍，这三种化合物对急性和慢性损伤的保护作用大致相同。