Sodicoff M, Conger A D
Radiat Res. 1983 Oct;96(1):90-4.
Most earlier studies showing a radioprotective effect by cAMP show only slight degrees of protection. The present study demonstrates a substantial protective effect (DMF, 1.63) of exogenously administered cAMP on the rat parotid gland and supports the mechanism suggested previously for protection afforded the parotid glands by the beta-adrenergic agonist isoproterenol, which is known to elevate endogenous intracellular cAMP.
大多数早期显示环磷酸腺苷（cAMP）具有辐射防护作用的研究仅表明有轻微程度的保护。本研究证明，外源性给予的cAMP对大鼠腮腺具有显著的保护作用（剂量效应因子，1.63），并支持先前提出的关于β-肾上腺素能激动剂异丙肾上腺素对腮腺提供保护的机制，已知该激动剂可提高内源性细胞内cAMP水平。
