环磷酸腺苷对大鼠腮腺的辐射防护作用
Radioprotection of the rat parotid gland by cAMP.
作者信息
Sodicoff M, Conger A D
出版信息
Radiat Res. 1983 Oct;96(1):90-4.
PMID:6312484
Abstract
Most earlier studies showing a radioprotective effect by cAMP show only slight degrees of protection. The present study demonstrates a substantial protective effect (DMF, 1.63) of exogenously administered cAMP on the rat parotid gland and supports the mechanism suggested previously for protection afforded the parotid glands by the beta-adrenergic agonist isoproterenol, which is known to elevate endogenous intracellular cAMP.
摘要
大多数早期显示环磷酸腺苷（cAMP）具有辐射防护作用的研究仅表明有轻微程度的保护。本研究证明，外源性给予的cAMP对大鼠腮腺具有显著的保护作用（剂量效应因子，1.63），并支持先前提出的关于β-肾上腺素能激动剂异丙肾上腺素对腮腺提供保护的机制，已知该激动剂可提高内源性细胞内cAMP水平。
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