Bhatti Abu Bakar Hafeez, Haq Ihsan Ul, Ahmed Imran Nazir, Bilal Raenah, Dar Faisal Saud
Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad.
Department of Pathology, Shifa International Hospital, Islamabad.
J Coll Physicians Surg Pak. 2018 Jun;28(6):490-491. doi: 10.29271/jcpsp.2018.06.490.
Intraoperative cholangiogram with cholecystectomy is a routinely performed procedure in living donor liver transplantation (LDLT).The objective of this study was to determine the frequency of gall bladder pathology in healthy living donors and whether routine histopathology can be omitted. This was a retrospective review of 366 donors who underwent donor hepatectomy between 2012 and 2016. Primary outcome of interest was frequency of abnormal histopathology findings in removed gall bladder specimen; and if their distribution was different with respect to gender, age and BMI. Male to female ratio was 2.1:1. Median age was 26 (18-50) years. Median BMI was 23.9 (15.7-35) Kg/m2. The most common finding was chronic cholecystitis in 189 (51.6%). Gall bladder pathology was more frequently seen in donors with BMI >25 Kg/m2, i.e. 69.3 % versus 30.7% (p<0.001). Due to high frequency of abnormal findings, gall bladder should be sent routinely for histopathology in healthy liver donors after cholecystectomy.
在活体肝移植（LDLT）中，术中胆管造影联合胆囊切除术是一种常规操作。本研究的目的是确定健康活体供体中胆囊病变的发生率，以及是否可以省略常规组织病理学检查。这是一项对2012年至2016年间接受供肝切除术的366名供体的回顾性研究。主要关注的结果是切除的胆囊标本中组织病理学异常发现的频率；以及它们在性别、年龄和BMI方面的分布是否不同。男女比例为2.1:1。中位年龄为26岁（18 - 50岁）。中位BMI为23.9（15.7 - 35）kg/m²。最常见的发现是189例（51.6%）慢性胆囊炎。BMI > 25 kg/m²的供体中胆囊病变更为常见，即69.3%对30.7%（p < 0.001）。由于异常发现的频率较高，胆囊切除术后的健康肝供体应常规送检胆囊进行组织病理学检查。
