Pirlamarla Aneesh K, Tang Justin, Amin Bijal, Kabarriti Rafi
Department of Radiation Oncology, Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, NY, U.S.A.
Department of Pathology, Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, NY, U.S.A.
Anticancer Res. 2018 Jun;38(6):3763-3766. doi: 10.21873/anticanres.12658.
BACKGROUND/AIM: Orbital metastasis of systemic cancer is exceedingly rare. This is a case report of a patient treated for locally recurrent vulvar melanoma who later presented with unilateral proptosis and was found to have an isolated biopsy-proven extraocular muscle metastasis.
A 94-year-old female with locally recurrent vulvar melanoma presented with eye discomfort and blurry vision. Patient underwent histopathological, genetic, and imaging studies.
All prior work-up, including brain MRI and PET/CT, was negative for disease elsewhere from local recurrence. Orbital MRI demonstrated a mass involving the extraocular muscle, and immunohistochemistry staining of biopsy was consistent with metastasis. The patient underwent radiation therapy and tolerated treatment well.
This is the first reported case of vulvar melanoma with extraocular muscle metastasis. The absence of findings on imaging as part of the staging work-up underscores the importance of considering extraocular muscle (EOM) metastasis as a differential for patients with vulvar melanoma who present with proptosis.
背景/目的：系统性癌症的眼眶转移极为罕见。本文报告一例局部复发性外阴黑色素瘤患者，该患者后来出现单侧眼球突出，经活检证实为孤立性眼外肌转移。
一名94岁女性，患有局部复发性外阴黑色素瘤，出现眼部不适和视力模糊。患者接受了组织病理学、基因和影像学检查。
包括脑部MRI和PET/CT在内的所有先前检查均未发现局部复发以外其他部位的疾病。眼眶MRI显示一个累及眼外肌的肿块，活检的免疫组织化学染色结果与转移相符。患者接受了放射治疗，耐受性良好。
这是首例报道的外阴黑色素瘤眼外肌转移病例。作为分期检查一部分的影像学检查未发现异常，这凸显了对于出现眼球突出的外阴黑色素瘤患者，将眼外肌转移作为鉴别诊断的重要性。
