Hikita Atsuhiko
Department of Cell & Tissue Engineering（Fujisoft）, Graduate School of Medicine, University of Tokyo, Japan.
Clin Calcium. 2018;28(6):825-831.
Mesenchymal stem cells(MSCs)are reported to have not only multipotency, but also anti-inflammatory and tissue repairing effects. Assays using animal models for osteoarthritis show that MSCs suppress the degeneration of cartilage. Based on these data, clinical researches and clinical trials have been performed for the treatment of osteoarthritis using MSCs. Results of these trials show the safety of the treatment, improvement of the symptoms, and findings indicating the cartilage repair. For the industrialization of the treatment using MSCs, application of allogenic cells has many advantages, while issues such as the immune reaction must be overcome.
据报道，间充质干细胞（MSCs）不仅具有多能性，还具有抗炎和组织修复作用。使用骨关节炎动物模型的试验表明，MSCs可抑制软骨退变。基于这些数据，已经开展了使用MSCs治疗骨关节炎的临床研究和临床试验。这些试验结果显示了该治疗方法的安全性、症状改善情况以及表明软骨修复的研究结果。对于使用MSCs的治疗方法的产业化而言，应用同种异体细胞具有许多优势，但必须克服免疫反应等问题。
