College of Human Science and Social Innovation, HungKuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung 43302, Taiwan.
Department of Plant Pathology, National Chung Hsing University, Taichung 402 Taiwan.
Int J Environ Res Public Health. 2018 May 30;15(6):1110. doi: 10.3390/ijerph15061110.
There have been few studies investigating interactions of G-protein beta3 subunit () C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity. The study aims to evaluate joint effects of polymorphisms and sodium consumption on the development of hypertension. A cohort-based case-control study was conducted in 2014. There are 233 participants with newly diagnosed hypertension in the case group and 699 participants in the gender-matched control group. The primary outcome is the development of hypertension over a 10-year period. The determinants of hypertension were three genotypes of SNP in (TT; CT; and CC) and two dietary salt categories on the basis of the level of sodium consumption representing high (>4800 mg/day) and low-sodium (.
关于 G 蛋白β3 亚单位（GNB3）C825T（rs5443）和膳食钠摄入量对高血压风险（即血压盐敏感性）的相互作用，研究甚少。本研究旨在评估多态性和钠摄入量对高血压发展的联合影响。2014 年进行了一项基于队列的病例对照研究。在病例组中有 233 名新诊断为高血压的参与者，对照组中有 699 名性别匹配的参与者。主要结局是在 10 年内发生高血压。高血压的决定因素是 SNP 的三种基因型（TT；CT；CC）和两种膳食盐类，根据钠摄入量水平分为高盐（>4800mg/天）和低盐（<2400mg/天）两类。
