Franceschini Nora, Chasman Daniel I, Cooper-DeHoff Rhonda M, Arnett Donna K
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, 137 E. Franklin St., Suite 306, Chapel Hill, NC, USA,
Curr Hypertens Rep. 2014 Aug;16(8):461. doi: 10.1007/s11906-014-0461-9.
Hypertension is the most common chronic condition seen by physicians in ambulatory care and a condition for which life-long medications are commonly prescribed. There is evidence for genetic factors influencing blood pressure variation in populations and response to medications. This review summarizes recent genetic discoveries that surround blood pressure, hypertension, and antihypertensive drug response from genome-wide association studies, while highlighting ancestry-specific findings and any potential implication for drug therapy targets. Genome-wide association studies have identified several novel loci for inter-individual variation of blood pressure and hypertension risk in the general population. Evidence from pharmacogenetic studies suggests that genes influence the blood pressure response to antihypertensive drugs, although results are somewhat inconsistent across studies. There is still much work that remains to be done to identify genes both for efficacy and adverse events of antihypertensive medications.
高血压是门诊医生最常诊治的慢性病，通常需要长期用药。有证据表明，遗传因素会影响人群血压变化以及对药物的反应。本综述总结了全基因组关联研究中有关血压、高血压和抗高血压药物反应的最新遗传发现，同时强调了特定血统的研究结果以及对药物治疗靶点的潜在影响。全基因组关联研究已经确定了普通人群中个体间血压变化和高血压风险的几个新位点。药物遗传学研究的证据表明，基因会影响抗高血压药物的血压反应，尽管各研究结果存在一定差异。在确定抗高血压药物疗效和不良事件相关基因方面，仍有许多工作要做。
