Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
Sci Rep. 2018 May 30;8(1):8422. doi: 10.1038/s41598-018-26316-5.
Mild stroke is a known risk factor for dementia. The relationship between cerebral white matter (WM) integrity and cognitive impairment (CI) in mild stroke patients with basal ganglia region infarcts is unknown. Total of 33 stroke patients and 19 age-matched controls underwent diffusion tensor imaging scans and a formal neuropsychological test battery. CI was defined as having a performance score 1.5 SD below the established norm. We compared the differences in Z-scores and Fraction Anisotropy (FA) values among controls, stroke with no CI (NCI) and stroke with CI groups. Multiple linear regressions were performed between FA values in affected regions and neuropsychological tests in stroke patients. The majority of stroke patients were in their 50s (56.90 ± 9.23 years). CI patients exhibited a significantly decreased Z score in visual delayed memory and remarkably decreased FA values in the right external capsule and right fornix (FWE-corrected) compared with NCI patients and controls. In stroke patients, the FA value in the right fornix was positively correlated with delayed visual memory. Mild stroke with basal ganglia region infarcts may be related to widespread abnormality of WM integrity. The lower WM integrity in the right fornix may be a marker of impaired delayed visual memory.
轻度中风是痴呆的已知危险因素。基底节区域梗死的轻度中风患者脑白质(WM)完整性与认知障碍(CI)之间的关系尚不清楚。共有 33 名中风患者和 19 名年龄匹配的对照者接受了弥散张量成像扫描和正式的神经心理学测试。CI 的定义为表现得分比既定标准低 1.5 个标准差。我们比较了对照组、无 CI(NCI)和 CI 组中风患者的 Z 分数和各向异性分数(FA)值之间的差异。在中风患者中,我们在受影响区域的 FA 值与神经心理学测试之间进行了多元线性回归。大多数中风患者年龄在 50 多岁(56.90±9.23 岁)。与 NCI 患者和对照组相比,CI 患者的视觉延迟记忆 Z 分数显著降低,右侧外囊和右侧穹窿的 FA 值显著降低(FWE 校正)。在中风患者中,右侧穹窿的 FA 值与延迟视觉记忆呈正相关。基底节区域梗死的轻度中风可能与 WM 完整性的广泛异常有关。右侧穹窿较低的 WM 完整性可能是延迟视觉记忆受损的标志物。