Cho Soo-Jin, Yu Kyung-Ho, Oh Mi Sun, Jung San, Lee Ju-Hun, Koh Im-Seok, Bae Hee-Joon, Kang Yeonwook, Lee Byung-Chul
Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, South Korea.
Department of Neurology, Hallym University College of Medicine, Anyang, South Korea.
BMC Neurol. 2014 Dec 20;14:244. doi: 10.1186/s12883-014-0244-6.
The American Stroke Association/American Heart Association recommended the criteria for diagnosis of vascular cognitive impairment and memory impairment (MI) is a feature in the classification of vascular mild cognitive impairment (VaMCI). VaMCI patients with MI may differ in terms of infarct location or demographic features, so we evaluated the clinical characteristics associated with MI in patients with VaMCI.
A prospective multicenter study enrolled 353 acute ischemic stroke patients who underwent evaluation using the Korean Vascular Cognitive Impairment Harmonization Standard Neuropsychological Protocol at three months after onset. The association between MI and demographic features, stroke risk factors, and infarct location was assessed.
VaMCI was diagnosed in 141 patients, and 58 (41.1%) exhibited MI. Proportions of men and of left side infarcts were higher in VaMCI with MI than those without (75.9 vs. 57.8%, P = 0.03, 66.7 vs. 47%, P = 0.02). Multiple logistic analyses revealed that male sex (odds ratio [OR] 3.07, 95% confidence interval [95% CI] 1.12-8.42), left-side infarcts (OR 3.14, 95% CI 1.37-7.20), and basal ganglia/internal capsule infarcts (OR 4.53, 95% CI 1.55-13.22) were associated with MI after adjusting other demographic variables, vascular risk factors, and subtypes of stroke.
MI is associated with sex and infarct location in VaMCI patients.
美国心脏协会/美国卒中协会推荐的血管性认知障碍诊断标准中，记忆障碍（MI）是血管性轻度认知障碍（VaMCI）分类中的一个特征。伴有MI的VaMCI患者在梗死部位或人口统计学特征方面可能存在差异，因此我们评估了VaMCI患者中与MI相关的临床特征。
一项前瞻性多中心研究纳入了353例急性缺血性卒中患者，这些患者在发病三个月后使用韩国血管性认知障碍协调标准神经心理学方案进行评估。评估了MI与人口统计学特征、卒中危险因素和梗死部位之间的关联。
141例患者被诊断为VaMCI，其中58例（41.1%）存在MI。伴有MI的VaMCI患者中男性比例和左侧梗死比例高于无MI的患者（75.9%对57.8%，P = 0.03；66.7%对47%，P = 0.02）。多因素逻辑分析显示，在调整了其他人口统计学变量、血管危险因素和卒中亚型后，男性（比值比[OR] 3.07，95%置信区间[95% CI] 1.12 - 8.42）、左侧梗死（OR 3.14，95% CI 1.37 - 7.20）和基底节/内囊梗死（OR 4.53，95% CI 1.55 - 13.22）与MI相关。
VaMCI患者的MI与性别和梗死部位有关。
