Korea Food Research Institute, Wanju-gun, 55365 Jeollabuk-do, Republic of Korea.
The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA.
Oxid Med Cell Longev. 2018 Apr 3;2018:5967150. doi: 10.1155/2018/5967150. eCollection 2018.
(Krachaidum (KD)) is a traditional herbal medicine and has properties that are beneficial for human health. In the current study, we sought to investigate the anti-inflammatory properties of KD extract (KPE). In mouse skin tissue, UV light representing solar wavelengths (sUV) increased COX-2 expression, while treatment with KPE reduced this effect. The anti-inflammatory activity of KPE was confirmed in models. MAPK signaling pathways were activated by sUV irradiation, and this was also repressed in the presence of KPE treatment. It is assumed that the anti-inflammatory activity of KPE is caused by the antioxidative effect. Furthermore, we confirmed the critical role of oxidative stress in sUV-induced COX-2 expression. We analyzed the polyphenol composition of KPE. Of the polyphenols identified, gallic acid, apigenin, and tangeretin were identified as the major polyphenols (at 9.31 ± 1.27, 2.37 ± 0.14, and 2.15 ± 0.19 g/mg dry weight, resp.). Collectively, these findings show that in the presence of sUV irradiation, KD has anti-inflammatory properties and antioxidative effects in the skin.
（Krachaidum (KD)）是一种传统的草药，具有有益于人类健康的特性。在目前的研究中，我们试图研究 KD 提取物 (KPE) 的抗炎特性。在小鼠皮肤组织中，代表太阳波长的紫外线 (sUV) 增加了 COX-2 的表达，而 KPE 处理则降低了这种作用。KPE 的抗炎活性在模型中得到了证实。MAPK 信号通路被 sUV 照射激活，而在存在 KPE 处理的情况下，这种作用也被抑制。据推测，KPE 的抗炎活性是由于其抗氧化作用。此外，我们还证实了氧化应激在 sUV 诱导的 COX-2 表达中的关键作用。我们分析了 KPE 的多酚组成。在所鉴定的多酚中，鉴定出没食子酸、芹菜素和橘红素为主要多酚（分别为 9.31±1.27、2.37±0.14 和 2.15±0.19 g/mg 干重）。总之，这些发现表明，在存在 sUV 照射的情况下，KD 具有抗炎特性和抗氧化作用在皮肤中。
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