Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Can J Gastroenterol Hepatol. 2018 Apr 3;2018:1940592. doi: 10.1155/2018/1940592. eCollection 2018.
Gastric varices (GV) are associated with high morbidity and mortality in patients with portal hypertension. Endoscopic cyanoacrylate injection is the first-line recommended therapy for GV obliteration. This study aims to explore the reason behind related adverse events and better prevent its occurrence.
A retrospective case series study was conducted from January 1, 2013, to December 31, 2016, to identify patients who experienced severe adverse events secondary to endoscopic cyanoacrylate injection. A literature review of similar cases was performed on two medical databases, Medline and Embase.
A total of 652 patients underwent cyanoacrylate injection at our center within the study duration. Five cases of severe adverse events related to the use of tissue adhesives were identified. Detailed clinical presentation, patient treatment, and outcomes were reviewed and analyzed. Twenty-seven similar cases were identified based on the literature review providing further insight into the study.
Although rare in incidence, systemic embolism associated with cyanoacrylate injection is often fatal or debilitating. This report may raise awareness in treatment protocol, including the necessity of preoperative angiographic studies, to avoid similar adverse events in clinical practice.
胃静脉曲张（GV）与门静脉高压症患者的高发病率和死亡率相关。内镜氰基丙烯酸酯注射是 GV 闭塞的首选治疗方法。本研究旨在探讨相关不良事件的原因，以便更好地预防其发生。
对 2013 年 1 月 1 日至 2016 年 12 月 31 日期间接受内镜氰基丙烯酸酯注射的患者进行了回顾性病例系列研究，以确定因内镜氰基丙烯酸酯注射而发生严重不良事件的患者。在 Medline 和 Embase 两个医学数据库中对类似病例进行了文献复习。
在研究期间，我们中心共有 652 例患者接受了氰基丙烯酸酯注射。发现 5 例与组织粘合剂使用相关的严重不良事件。详细的临床表现、患者治疗和结局进行了回顾和分析。根据文献复习，共确定了 27 例类似病例，为研究提供了更深入的了解。
尽管发生率较低，但与氰基丙烯酸酯注射相关的全身栓塞常常是致命的或使患者致残的。本报告可能会提高治疗方案的认识，包括术前血管造影研究的必要性，以避免在临床实践中发生类似的不良事件。
