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通气患者延迟发生的肺胶水栓塞:内镜下注射氰基丙烯酸酯治疗胃静脉曲张出血后的罕见并发症。

Delayed onset pulmonary glue emboli in a ventilated patient: a rare complication following endoscopic cyanoacrylate injection for gastric variceal haemorrhage.

作者信息

Chew Joyce Ruo Yi, Balan Anu, Griffiths William, Herre Jurgen

机构信息

Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK.

Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.

出版信息

BMJ Case Rep. 2014 Oct 15;2014:bcr2014206461. doi: 10.1136/bcr-2014-206461.

Abstract

Cyanoacrylate injection is a recognised endoscopic treatment option for variceal haemorrhage. We describe a 34-year old man with hepatitis B cirrhosis who presented to the hospital with upper gastrointestinal haemorrhage from gastric and oesophageal varices. Haemostasis was achieved via cyanoacrylate injection sclerotherapy and banding. Ten days later, the patient developed acute hypoxia and fever. His chest radiograph showed wide-spread pulmonary shadowing. A non-contrast CT scan confirmed multiple emboli of injected glue material from the varix with parenchymal changes either suggesting acute lung injury or pulmonary oedema. He gradually recovered with supportive treatment and was discharged home. On follow-up, he remained asymptomatic from a chest perspective. This case report discusses the rare complication of pulmonary embolisation of cyanoacrylate glue from variceal injection sites and the diagnostic dilemmas involved. Emphasis is placed on the importance of maintaining high index of clinical suspicion when assessing patients with possible procedure related complications.

摘要

氰基丙烯酸酯注射是一种公认的内镜下治疗静脉曲张出血的方法。我们描述了一名34岁的乙型肝炎肝硬化男性,因胃和食管静脉曲张导致上消化道出血入院。通过氰基丙烯酸酯注射硬化疗法和套扎术实现了止血。十天后,患者出现急性缺氧和发热。他的胸部X光片显示广泛的肺部阴影。非增强CT扫描证实从静脉曲张注射的胶水材料出现多处栓塞,并伴有实质性改变,提示急性肺损伤或肺水肿。经过支持治疗,他逐渐康复并出院回家。随访时,从胸部情况来看他仍无症状。本病例报告讨论了静脉曲张注射部位氰基丙烯酸酯胶水肺栓塞这一罕见并发症以及所涉及的诊断难题。强调了在评估可能与手术相关并发症的患者时保持高度临床怀疑的重要性。

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