[Synthesis and biological activity of analogs of a nonapeptide inhibitor of peptidyldipeptidase].
作者信息
Filatova M P, Krit N A, Beschastnaia N V, Blokhina A V, Kozlova N I
出版信息
Bioorg Khim. 1985 Jan;11(1):21-30.
PMID:2985089
Abstract
The synthesis of 5 analogues of the effective inhibitor of peptidyl dipeptidase, teprotide, has been carried out. The inhibitory and bradykinin-potentiating activity of these compounds has been assayed. N-Terminal pyroglutamic acid and positive charge of arginine in position 4 were found to be essential for biological activity of the inhibitor.
摘要
Zotero 插件