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视交叉上核损毁可消除大鼠脑内神经递质受体的昼夜节律。

Suprachiasmatic nucleus ablation abolishes circadian rhythms in rat brain neurotransmitter receptors.

作者信息

Kafka M S, Marangos P J, Moore R Y

出版信息

Brain Res. 1985 Feb 18;327(1-2):344-7. doi: 10.1016/0006-8993(85)91533-1.

DOI:10.1016/0006-8993(85)91533-1
PMID:2985180
Abstract

The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation resulted in loss of circadian, but not ultradian, rhythms, without change in the 24-h mean numbers. SCN ablation appears to cause a selective loss of circadian function in the regulation of brain receptors.

摘要

研究了视交叉上核(SCN)消融对脑神经递质受体节律的影响。在对照动物中,α-肾上腺素能受体和苯二氮䓬受体数量的节律是昼夜节律性的,而β-肾上腺素能受体和乙酰胆碱受体的节律是超日节律性的。SCN消融导致昼夜节律而非超日节律丧失,24小时平均数量无变化。SCN消融似乎在脑受体调节中导致昼夜节律功能的选择性丧失。

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