Wollnik F, Turek F W
Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208.
Am J Physiol. 1989 May;256(5 Pt 2):R1027-39. doi: 10.1152/ajpregu.1989.256.5.R1027.
A trimodal locomotor activity pattern has been observed in LEW/Ztm rats. Complete and partial lesions of the suprachiasmatic nucleus (SCN) were used to determine whether the same neural substrate may underlie the circadian rhythms and the ultradian modulation of wheel-running activity in these rats. Whereas sham lesions had little or no effect on the wheel-running activity pattern, complete SCN lesions resulted in a complete loss of circadian and ultradian activity components under free-running or 12:12 h light-dark cycle (12:12 LD) conditions. Ultradian and circadian activity components were still present after partial SCN lesions. Periodogram analysis for any given animal revealed that the ultradian periods were always submultiples of the entrained or free-running circadian period. Furthermore there was a high correlation between the amplitudes of circadian and ultradian spectral estimates, but with a different slope in males and females. These results indicate that in LEW/Ztm rats the SCN contributes to the control of both the circadian wheel-running rhythm and the trimodal ultradian modulation of that behavior.
在LEW/Ztm大鼠中观察到了一种三峰运动活动模式。采用视交叉上核（SCN）的完全性和部分性损伤，以确定相同的神经基质是否可能是这些大鼠昼夜节律和轮转运动活动的超日节律调节的基础。假损伤对轮转运动活动模式几乎没有影响或没有影响，而完全性SCN损伤导致在自由活动或12:12小时明暗循环（12:12 LD）条件下，昼夜节律和超日活动成分完全丧失。部分SCN损伤后，超日和昼夜活动成分仍然存在。对任何给定动物的周期图分析表明，超日周期总是夹带或自由运行的昼夜周期的约数。此外，昼夜和超日频谱估计的幅度之间存在高度相关性，但雄性和雌性的斜率不同。这些结果表明，在LEW/Ztm大鼠中，SCN有助于控制昼夜轮转运动节律以及该行为的三峰超日调节。
