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预测接受矫正手术的青少年特发性脊柱侧凸患者的大量输血:术前影像学检查结果的相关性

Predicting massive transfusion in adolescent idiopathic scoliosis patients undergoing corrective surgery: Association of preoperative radiographic findings.

作者信息

Kim Ha-Jung, Park Hee-Sun, Jang Min-Jeong, Koh Won Uk, Song Jun-Gol, Lee Choon-Sung, Yang Hong-Seuk, Ro Young-Jin

机构信息

Department of Anesthesiology and Pain Medicine Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

Medicine (Baltimore). 2018 Jun;97(22):e10972. doi: 10.1097/MD.0000000000010972.

Abstract

Corrective surgery with a posterior approach for adolescent idiopathic scoliosis (AIS) is often accompanied by considerable bleeding. Massive transfusion after excessive hemorrhage is associated with complications such as hypothermia, coagulopathy, and acid-base imbalance. Therefore, prediction and prevention of massive transfusion are necessary to improve the clinical outcome of AIS patients. We aimed to identify the factors associated with massive transfusion in AIS patients undergoing corrective surgery. We also evaluated the clinical outcomes after massive transfusion.We included and analyzed AIS patients who underwent corrective surgery with a posterior approach from January 2008 to February 2015. We retrospectively reviewed the electronic medical records of 765 consecutive patients. We performed multivariable logistic regression analysis to assess the factors related to massive transfusion. Furthermore, we compared the effects of massive transfusion on clinical outcomes, including postoperative morbidity and hospital stay.Of 765 patients, 74 (9.7%) received massive transfusion. Body mass index (odds ratio [OR] 0.782, 95% confidence interval [CI] 0.691-0.885, P < .001) and the number of fused vertebrae (OR 1.322, 95% CI 1.027-1.703, P = .03) were associated with massive transfusion. In the comparison among the different Lenke curve types, Lenke type 4 showed the highest prevalence of massive transfusion. Patients in the massive transfusion group showed a higher incidence rate of postoperative morbidity and prolonged hospital stay.Massive transfusion was required in 9.7% of AIS patients who underwent corrective surgery with a posterior approach. A lower body mass index and higher number of fused vertebrae were associated with massive transfusion. Massive transfusion is related to poor clinical outcomes in AIS patients.

摘要

青少年特发性脊柱侧凸(AIS)后路矫正手术常伴有大量出血。大量失血后的大量输血与低体温、凝血功能障碍和酸碱失衡等并发症相关。因此,预测和预防大量输血对于改善AIS患者的临床结局很有必要。我们旨在确定接受矫正手术的AIS患者发生大量输血的相关因素。我们还评估了大量输血后的临床结局。我们纳入并分析了2008年1月至2015年2月接受后路矫正手术的AIS患者。我们回顾性分析了连续765例患者的电子病历。我们进行多变量逻辑回归分析以评估与大量输血相关的因素。此外,我们比较了大量输血对临床结局的影响,包括术后发病率和住院时间。765例患者中,有74例(9.7%)接受了大量输血。体重指数(优势比[OR]0.782,95%置信区间[CI]0.691-0.885,P<0.001)和融合椎体数量(OR 1.3,22,95%CI 1.027-1.703,P=0.03)与大量输血相关。在不同Lenke曲线类型的比较中,Lenke 4型大量输血的发生率最高。大量输血组患者术后发病率较高,住院时间延长。接受后路矫正手术的AIS患者中有9.7%需要大量输血。较低的体重指数和较多的融合椎体数量与大量输血相关。大量输血与AIS患者不良的临床结局相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e9a/6392981/38eb56bf3c8b/medi-97-e10972-g001.jpg

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