Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Drug Discov Today. 2019 Jan;24(1):233-240. doi: 10.1016/j.drudis.2018.05.032. Epub 2018 May 28.
Cumulative evidence has proven that proliferation, differentiation and migration of cardiac stem cells (CSCs) dominate early heart development and contribute to the later occurrence of heart disease. Among other mechanisms, microRNAs work as the 'fine-tuning' to modulate the levels of target genes in a specific cell type. The distinct microRNA signatures in CSCs reveal the stages and functions of CSCs. The focus of this review is to summarize recent knowledge advances in CSC proliferation, differentiation and migration and to discuss how microRNAs regulate these processes during heart development and in heart disease. Better understanding of microRNA regulation on CSCs under different situations will enable the unveiling of the mechanisms of heart disease and open new avenues in the therapeutic potentials of microRNA modulation to treat heart disease.
已有大量证据表明,心脏干细胞(CSC)的增殖、分化和迁移主导着心脏的早期发育,并导致后期发生心脏病。在其他机制中,microRNAs 作为“微调”因子,在特定细胞类型中调节靶基因的水平。CSC 中独特的 microRNA 特征揭示了 CSC 的阶段和功能。本综述的重点是总结 CSC 增殖、分化和迁移的最新知识进展,并讨论 microRNAs 如何在心脏发育和心脏病中调节这些过程。更好地了解不同情况下 microRNA 对 CSC 的调节,将有助于揭示心脏病的机制,并为 microRNA 调节治疗心脏病的治疗潜力开辟新途径。