Joladarashi Darukeshwara, Thandavarayan Rajarajan Amirthalingam, Babu Sahana Suresh, Krishnamurthy Prasanna
Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA.
Int J Mol Sci. 2014 Sep 9;15(9):15891-911. doi: 10.3390/ijms150915891.
Cardiac diseases are the predominant cause of human mortality in the United States and around the world. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to modulate a wide range of biological functions under various pathophysiological conditions. miRNAs alter target expression by post-transcriptional regulation of gene expression. Numerous studies have implicated specific miRNAs in cardiovascular development, pathology, regeneration and repair. These observations suggest that miRNAs are potential therapeutic targets to prevent or treat cardiovascular diseases. This review focuses on the emerging role of miRNAs in cardiac development, pathogenesis of cardiovascular diseases, cardiac regeneration and stem cell-mediated cardiac repair. We also discuss the novel diagnostic and therapeutic potential of these miRNAs and their targets in patients with cardiac diseases.
在美国及全球范围内，心脏疾病是人类死亡的主要原因。微小RNA（miRNA）是一类小的非编码RNA，已证实在各种病理生理条件下可调节多种生物学功能。miRNA通过对基因表达的转录后调控来改变靶标表达。大量研究表明特定的miRNA与心血管发育、病理、再生及修复有关。这些观察结果提示miRNA是预防或治疗心血管疾病的潜在治疗靶点。本综述重点关注miRNA在心脏发育、心血管疾病发病机制、心脏再生及干细胞介导的心脏修复中的新作用。我们还讨论了这些miRNA及其靶标在心脏病患者中的新型诊断和治疗潜力。
