Shen Qiqin, Wu Lingdi, Cai Chuyi, Li Bingbing, Yu Fang
Department of Spine Surgery, Shaoxing Central Hospital, Affiliated Central Hospital of Shaoxing University, Shaoxing, Zhejiang Province, China.
Department of Radiology, Ningbo No. 2 Hospital, Ningbo, Zhejiang Province, China.
Front Neurosci. 2025 Jun 25;19:1622787. doi: 10.3389/fnins.2025.1622787. eCollection 2025.
Spinal cord injury (SCI) is a traumatic neurological disorder with a high incidence and limited clinical treatment options. Ferroptosis, a newly discovered form of programmed cell death, has shown significant research potential in the field of neurological diseases. Stem cells have become an ideal therapeutic option for various diseases due to their multidirectional differentiation potential and paracrine properties. Existing studies have demonstrated that stem cells possess substantial potential in the repair of spinal cord injuries. Recent research has found that stem cell transplantation can improve the pathological process of SCI by regulating the ferroptosis pathway. This review systematically described the molecular mechanisms of ferroptosis in SCI, the biological effects of stem cell therapy for SCI, and the therapeutic potential of stem cell-targeted regulation of ferroptosis. Additionally, we proposed three key research directions: cross-study of ferroptosis signaling pathways and stem cell action mechanisms, optimization strategies for therapeutic stem cells, and multimodal combined treatments based on ferroptosis regulation. This review aimed to provide new theoretical foundations and research perspectives for stem cell therapy in SCI.
脊髓损伤（SCI）是一种创伤性神经疾病，发病率高且临床治疗选择有限。铁死亡是一种新发现的程序性细胞死亡形式，在神经疾病领域已显示出巨大的研究潜力。干细胞因其多向分化潜能和旁分泌特性，已成为各种疾病的理想治疗选择。现有研究表明，干细胞在脊髓损伤修复方面具有巨大潜力。最近的研究发现，干细胞移植可通过调节铁死亡途径改善脊髓损伤的病理过程。本综述系统地描述了脊髓损伤中铁死亡的分子机制、干细胞治疗脊髓损伤的生物学效应以及干细胞靶向调节铁死亡的治疗潜力。此外，我们提出了三个关键研究方向：铁死亡信号通路与干细胞作用机制的交叉研究、治疗性干细胞的优化策略以及基于铁死亡调节的多模式联合治疗。本综述旨在为脊髓损伤的干细胞治疗提供新的理论基础和研究视角。
