College of Chemistry, Jilin University, Changchun 130012, PR China.
Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, PR China.
Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:257-263. doi: 10.1016/j.msec.2018.04.047. Epub 2018 Apr 17.
The present work reveals a new and simple one-pot green method to load doxorubicin (DOX) drugs in silica nanoparticles for efficient in vivo cancer therapy. The synthesis of DOX loaded silica nanoparticles (SiNPs/DOX) is based on the efficient encapsulation of DOX in surfactant Tween 80 micelles which act as a template for the formation of silica nanoparticles. The release profile, cellular uptake behavior, cytotoxicity and antitumor effect of SiNPs/DOX nanoparticles were investigated and compared to free DOX. The silica nanoparticles improved the cellular drug delivery efficiency and exhibited high cytotoxicity, successfully achieving the inhibition of tumor growth. Notably, the tumor size and weight of SiNPs/DOX group was 2-fold and 1.7-fold smaller than that of free DOX group, and 4-fold and 2-fold smaller than that of PBS group. The one-pot green synthesis system may have the potential to be developed as a promising drug delivery system.
本工作揭示了一种新的简单一锅绿色方法，可将阿霉素（DOX）药物载入二氧化硅纳米粒子中，以实现有效的体内癌症治疗。负载 DOX 的二氧化硅纳米粒子（SiNPs/DOX）的合成基于高效包封 DOX 在表面活性剂吐温 80 胶束中，该胶束作为形成二氧化硅纳米粒子的模板。研究了 SiNPs/DOX 纳米粒子的释放曲线、细胞摄取行为、细胞毒性和抗肿瘤作用，并与游离 DOX 进行了比较。二氧化硅纳米粒子提高了细胞内药物递送效率，并表现出高细胞毒性，成功抑制了肿瘤生长。值得注意的是，SiNPs/DOX 组的肿瘤大小和重量分别比游离 DOX 组小 2 倍和 1.7 倍，比 PBS 组小 4 倍和 2 倍。一锅绿色合成系统可能有潜力开发为一种有前途的药物传递系统。
