School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China; Department of Mechanical & Industrial Engineering, Northeastern University, Boston MA02115, USA.
School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China; IFW Dresden, Institute for Complex Materials, P.O. Box 27 01 16, D-01171 Dresden, Germany.
Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:8-15. doi: 10.1016/j.msec.2018.04.042. Epub 2018 Apr 17.
β-type Ti-35Nb-7Zr alloy has attracted considerable attentions as a bone implant material. The alloy, however, has poor bioactivity, which difficult to form a strong osseointegration between the bone tissues. Combining Ti alloy with a bioactive and biodegradable ceramic has been of interest to researchers. But the large difference in physicochemical property of high-melting metal and ceramic elements would bring the manufacturing restriction. In this work, Ti-35Nb-7Zr-CPP composites were fabricated with mechanical alloy of Ti, Nb, Zr and Nano calcium pyrophosphate (CPP) powders mixture followed by spark plasma sintering (SPS) routes. The effect of CPP ceramic on microstructural evolution and in vitro biocompatibility were investigated. As the addition of CPP (10-30 wt%), ceramic elements spreading towards the matrix, the generated metal-ceramic bioactive phases CaTiO are observed well consolidated with β-Ti matrix. With the CPP increasing, Ca and P atoms rapidly migrated to the β-Ti matrix to form granulated TiP, which leads to the increasing porosity (10%-18%) in the composites. The results demonstrated that the favorable cell viability (the cell proliferation rates were higher than 100%) and growth inside the pores of the composites arise from the rough micro-porous surface and the release of bioactive metal-ceramic phase ions into the biological environment. The enhanced bioactivity and microstructural evolution behaviors of the Ti-35Nb-7Zr-CPP composites may provide a strategy for designing and fabricating multifunctional implants.
β 型 Ti-35Nb-7Zr 合金作为一种骨植入材料引起了广泛关注。然而，该合金的生物活性较差，难以在骨组织之间形成牢固的骨整合。将钛合金与生物活性和可生物降解的陶瓷结合已经引起了研究人员的兴趣。但是，高熔点金属和陶瓷元素的物理化学性质的巨大差异会带来制造限制。在这项工作中，采用机械合金化 Ti、Nb、Zr 和纳米焦磷酸钙（CPP）粉末混合物，然后通过火花等离子烧结（SPS）路线制备了 Ti-35Nb-7Zr-CPP 复合材料。研究了 CPP 陶瓷对微观结构演变和体外生物相容性的影响。随着 CPP（10-30wt%）的添加，陶瓷元素向基体扩散，生成的金属-陶瓷生物活性相 CaTiO 与β-Ti 基体很好地结合在一起。随着 CPP 的增加，Ca 和 P 原子迅速迁移到β-Ti 基体中形成粒状 TiP，导致复合材料的孔隙率（10%-18%）增加。结果表明，良好的细胞活力（细胞增殖率高于 100%）和细胞在复合材料孔内的生长源于粗糙的微孔表面和生物活性金属-陶瓷相离子释放到生物环境中。Ti-35Nb-7Zr-CPP 复合材料的增强生物活性和微观结构演变行为可能为设计和制造多功能植入物提供了一种策略。
