无环嘧啶核苷类似物：对L5178y小鼠淋巴瘤细胞生长的影响及在KB细胞中的抗疱疹活性。
Acyclic pyrimidine nucleoside analogues: influence on growth of L5178y mouse lymphoma cells and antiherpes activity in KB cells.
作者信息
Allen L B, Schröder H C, Zahn R K, Stoss P, Maidhof A, Müller W E
出版信息
Chemotherapy. 1985;31(2):151-9. doi: 10.1159/000238328.
Several uracil and cytosine nucleoside analogues with 2-hydroxyethoxymethyl, 2-aminoethoxymethyl or 1,3-dihydroxypropoxymethyl side chains were synthesized and evaluated for cytostatic (L5178y mouse lymphoma cells) and antiviral (herpes simplex virus type 1 infected KB cells) activity. Two compounds exhibited antiherpesvirus activity. These were 1-(2'-hydroxyethoxymethyl)-5-aza-cytosine and 1-(1',3'-dihydroxypropoxymethyl)-5-iodouracil. The MIC values were 25.8 and 325.7 micrograms/ml, respectively.
合成了几种带有2-羟基乙氧基甲基、2-氨基乙氧基甲基或1,3-二羟基丙氧基甲基侧链的尿嘧啶和胞嘧啶核苷类似物，并对其进行了细胞生长抑制活性（针对L5178y小鼠淋巴瘤细胞）和抗病毒活性（针对单纯疱疹病毒1型感染的KB细胞）评估。两种化合物表现出抗疱疹病毒活性。它们分别是1-(2'-羟基乙氧基甲基)-5-氮杂胞嘧啶和1-(1',3'-二羟基丙氧基甲基)-5-碘尿嘧啶。其最低抑菌浓度值分别为25.8和325.7微克/毫升。
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