Rather Shagufta, Keen Abid, Sajad Peerzada
Department of Dermatology, Venereology and Leprology, Government Medical College, Srinagar, Jammu and Kashmir, India.
Indian Dermatol Online J. 2018 May-Jun;9(3):170-174. doi: 10.4103/idoj.IDOJ_74_17.
To evaluate the relationship between vitamin D levels and chronic spontaneous urticaria (CSU) and compare with healthy age and sex matched controls.
This was a hospital-based cross-sectional study conducted over a period of 1 year, in which 110 patients with CSU were recruited along with an equal number of sex and age-matched healthy controls. For each patient, urticaria activity score (UAS) was calculated and autologous serum skin test (ASST) was performed. Plasma 25-hydroxyvitamin D [25-(OH)D] was analyzed by chemiluminescence method. A deficiency in vitamin D was defined as serum 25-(OH)D concentrations <30 ng/mL. The statistical analysis was carried out by using appropriate statistical tests.
The mean serum 25-(OH)D levels of CSU patients was 19.6 ± 6.9 ng/mL, whereas in control group, the mean level was 38.5 ± 6.7, the difference being statistically significant ( < 0.001). A significant negative correlation was found between vitamin D levels and UAS. ( < 0.001). The number of patients with ASST positivity was 44 (40%).
The patients with CSU had reduced levels of vitamin D when compared to healthy controls. Furthermore, there was a significant negative correlation between the levels of serum vitamin D and severity of CSU.
评估维生素D水平与慢性自发性荨麻疹（CSU）之间的关系，并与年龄和性别匹配的健康对照进行比较。
这是一项基于医院的横断面研究，为期1年，招募了110例CSU患者以及同等数量年龄和性别匹配的健康对照。为每位患者计算荨麻疹活动评分（UAS）并进行自体血清皮肤试验（ASST）。采用化学发光法分析血浆25-羟基维生素D [25-(OH)D]。维生素D缺乏定义为血清25-(OH)D浓度<30 ng/mL。使用适当的统计检验进行统计分析。
CSU患者的平均血清25-(OH)D水平为19.6±6.9 ng/mL，而对照组的平均水平为38.5±6.7，差异具有统计学意义（<0.001）。维生素D水平与UAS之间存在显著负相关（<0.001）。ASST阳性患者人数为44例（40%）。
与健康对照相比，CSU患者的维生素D水平降低。此外，血清维生素D水平与CSU严重程度之间存在显著负相关。
