Akbar Nadeem A, Zacharek Mark A
Department of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
Curr Opin Otolaryngol Head Neck Surg. 2011 Jun;19(3):224-8. doi: 10.1097/MOO.0b013e3283465687.
To discuss the role of vitamin D in asthma, allergic rhinitis, and chronic rhinosinusitis (CRS).
Over the last several years, the role of vitamin D in immunomodulation has been studied and shown to have a significant impact on immune function. A causal relationship exists between vitamin D function and innate and adaptive immunity to infections. The mechanisms underlying vitamin D immune actions could be attributed to a paracrine feedback loop that reduces inflammation as well as influencing the differentiation fate of activated CD4 T cells, or the enhancement of suppressor T-cell function; indeed, a combination of these factors may underlie the actions of vitamin D.
Recent findings on the function of vitamin D may explain aspects of the pathophysiology of allergic rhinitis and CRS and may help direct future interventions and treatment of these diseases.
探讨维生素D在哮喘、过敏性鼻炎和慢性鼻-鼻窦炎（CRS）中的作用。
在过去几年中，对维生素D在免疫调节中的作用进行了研究，结果表明其对免疫功能有重大影响。维生素D功能与对感染的先天性和适应性免疫之间存在因果关系。维生素D免疫作用的潜在机制可能归因于旁分泌反馈回路，该回路可减轻炎症并影响活化的CD4 T细胞的分化命运，或增强抑制性T细胞功能；实际上，这些因素的组合可能是维生素D作用的基础。
关于维生素D功能的最新研究结果可能解释过敏性鼻炎和CRS病理生理学的某些方面，并可能有助于指导这些疾病未来的干预措施和治疗。
