Department of Neurology, Sichuan Provincial People's Hospital, The Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Department of Neurology, The Sixth People's Hospital of Chengdu, Chengdu, China.
Biomed Res Int. 2018 Apr 24;2018:4104691. doi: 10.1155/2018/4104691. eCollection 2018.
Recent epidemiological studies have indicated that the incidence of epilepsy peaks after 60 years old, and epilepsy has become increasingly prevalent in elderly populations. The aim of this study is to identify the aetiologic characteristics of epilepsy in the elderly.
We retrospectively recruited elderly patients with newly diagnosed epilepsy identified in three epilepsy centres in western China; elderly patients were defined as individuals aged 60 years or older. Demographic characteristics, clinical epilepsy data, and the diagnosis and aetiology of epilepsy were recorded.
A total of 760 patients with newly diagnosed epilepsy were enrolled in our study. Of these patients, 25% had experienced one or more episodes of status epilepticus, and 62.4% were confirmed as symptomatic. Among the symptomatic cohort, stroke and traumatic brain injury (TBI) were the two most common causes of epilepsy, followed by cerebral tumour, dementia, hippocampal sclerosis (HS), and central nervous system (CNS) infection. When analysed by residence and age, ischaemic stroke was the most common cause of epilepsy in urban patients, whereas traumatic brain injury was the leading cause of epilepsy in rural patients.
More than three-fifths of newly diagnosed epilepsy cases in elderly patients were confirmed as symptomatic, and stroke and traumatic brain injury were the primary aetiologies in elderly epileptic patients.
最近的流行病学研究表明，癫痫的发病率在 60 岁以后达到高峰，癫痫在老年人群中的发病率越来越高。本研究旨在确定老年人癫痫的病因特征。
我们回顾性招募了在中国西部三个癫痫中心确诊的新发癫痫老年患者；老年患者定义为年龄在 60 岁及以上的个体。记录人口统计学特征、临床癫痫数据以及癫痫的诊断和病因。
本研究共纳入了 760 例新发癫痫患者。其中，25%的患者经历过一次或多次癫痫持续状态，62.4%的患者被确诊为症状性。在症状性队列中，中风和创伤性脑损伤（TBI）是癫痫的两个最常见病因，其次是脑肿瘤、痴呆、海马硬化（HS）和中枢神经系统（CNS）感染。按居住地和年龄分析，缺血性中风是城市患者癫痫最常见的病因，而创伤性脑损伤是农村患者癫痫的主要病因。
五分之三以上的新发老年癫痫患者被确诊为症状性，中风和创伤性脑损伤是老年癫痫患者的主要病因。
